Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice

Autor: Luca Piali, Daniel J. Sussman, Yves D. Mathieu, Jason Gill, Richard L. Boyd, Georg A. Holländer, Egle Balciunaite, Gina Balciunaite, Marcel P. Keller, Saulius Zuklys
Rok vydání: 2002
Předmět:
Transcription
Genetic

Cellular differentiation
T-Lymphocytes
Dishevelled Proteins
Xenopus Proteins
Receptors
G-Protein-Coupled

Mice
Phosphatidylinositol 3-Kinases
Genes
Reporter

Wnt4 Protein
Morphogenesis
Immunology and Allergy
Enzyme Inhibitors
Phosphorylation
beta Catenin
Phosphoinositide-3 Kinase Inhibitors
Regulation of gene expression
integumentary system
biology
Lymphopoiesis
Wnt signaling pathway
Cell Differentiation
Forkhead Transcription Factors
3T3 Cells
DNA-Binding Proteins
Autocrine Communication
TCF Transcription Factors
Transcription Factor 7-Like 2 Protein
Beta-catenin
Lymphoid Enhancer-Binding Factor 1
Morpholines
Recombinant Fusion Proteins
Immunology
Mice
Nude

Receptors
Cell Surface

Thymus Gland
Protein Serine-Threonine Kinases
Wnt3 Protein
Paracrine signalling
Proto-Oncogene Proteins
Paracrine Communication
Animals
Autocrine signalling
Adaptor Proteins
Signal Transducing

Glycoproteins
FOXN1
Proteins
Epithelial Cells
Zebrafish Proteins
Phosphoproteins
Frizzled Receptors
Wnt Proteins
Cytoskeletal Proteins
Gene Expression Regulation
Chromones
Protein Biosynthesis
biology.protein
Cancer research
Trans-Activators
Protein Processing
Post-Translational

Proto-Oncogene Proteins c-akt
Lymphoid enhancer-binding factor 1
Transcription Factors
Zdroj: Nature immunology. 3(11)
ISSN: 1529-2908
Popis: T cell development and selection require the fully mature and diverse epithelial microenvironment of the thymus. Acquisition of these characteristics is dependent on expression of the forkhead (also known as winged-helix) transcription factor FoxN1, as a lack of functional FoxN1 results in aberrant epithelial morphogenesis and an inability to attract lymphoid precursors to the thymus primordium. However, the transcriptional control of Foxn1 expression has not been elucidated. Here we report that secreted Wnt glycoproteins, expressed by thymic epithelial cells and thymocytes, regulate epithelial Foxn1 expression in both autocrine and paracrine fashions. Wnt molecules therefore provide regulatory signals critical for thymic function.
Databáze: OpenAIRE