Metabolic control analysis of anaerobic glycolysis in human hibernating myocardium replaces traditional concepts of flux control
| Autor: | Albrecht Elsässer, Achim M. Vogt, Wolfgang Kübler, Jutta Schaper, Holger Nef, David A. Fell, Mark G. Poolman |
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| Rok vydání: | 2002 |
| Předmět: |
Biopsy
Glucose uptake Biophysics 030204 cardiovascular system & hematology Biology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ischemia Structural Biology Metabolic regulation Genetics medicine Humans Glycolysis Anaerobiosis Molecular Biology 030304 developmental biology Myocardial Stunning Hibernating myocardium 0303 health sciences Myocardial stunning Glycogen Energy metabolism Cell Biology medicine.disease Cell biology Perfusion Glucose chemistry Anaerobic glycolysis medicine.symptom Anaerobic exercise Flux (metabolism) |
| Zdroj: | FEBS Letters. 517:245-250 |
| ISSN: | 1873-3468 0014-5793 |
| DOI: | 10.1016/s0014-5793(02)02632-7 |
| Popis: | Myocardial hibernation represents an adaptation to sustained ischemia to maintain tissue vitality during severe supply–demand imbalance which is characterized by an increased glucose uptake. To elucidate this adaptive protective mechanism, the regulation of anaerobic glycolysis was investigated using human biopsies. In hibernating myocardium showing an increase in anaerobic glycolytic flux metabolizing exogenous glucose, the adjustment of flux through this pathway was analyzed by flux:metabolite co-responses. By this means, a previously unknown pattern of regulation using multisite modulation was found which largely differs from traditional concepts of metabolic control of the Embden–Meyerhof pathway in normal and diseased myocardium. |
| Databáze: | OpenAIRE |
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