Commitment of scaffold proteins in the onco-biology of human colorectal cancer and liver metastases after oxaliplatin-based chemotherapy

Autor: Manuel Morales, María del Carmen Maeso, María del Pino García, Ali Mobasheri, Deborah Rotoli, Pablo Martín-Vasallo, Julio Ávila
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Scaffold protein
Pathology
Organoplatinum Compounds
Colorectal cancer
0302 clinical medicine
IQGAP1
AmotL2
Telocytes
Spectroscopy
Liver Neoplasms
General Medicine
Immunohistochemistry
Computer Science Applications
Oxaliplatin
FOLFOX
Liver
ras GTPase-Activating Proteins
030220 oncology & carcinogenesis
Colorectal Neoplasms
medicine.drug
Cell type
medicine.medical_specialty
colorectal cancer
scaffold proteins
FKBP51
metastasized liver
oxaliplatin
pericytes
telocytes
Epithelial-Mesenchymal Transition
Colon
Antineoplastic Agents
Biology
Article
Catalysis
Tacrolimus Binding Proteins
Inorganic Chemistry
03 medical and health sciences
Immune system
Scaffold proteins
medicine
Humans
Epithelial–mesenchymal transition
Physical and Theoretical Chemistry
Molecular Biology
Metastasized liver
Organic Chemistry
medicine.disease
030104 developmental biology
Angiomotins
Microscopy
Fluorescence
Blood Vessels
Carrier Proteins
Pericytes
Immunostaining
Zdroj: International journal of molecular sciences (Online) 18 (2017). doi:10.3390/ijms18040891
info:cnr-pdr/source/autori:Rotoli D.; Morales M.; Avila J.; del Carmen Maeso M.; Garcia M.D.P.; Mobasheri A.; Martin-Vasallo P./titolo:Commitment of scaffold proteins in the onco-biology of human colorectal cancer and liver metastases after oxaliplatin-based chemotherapy/doi:10.3390%2Fijms18040891/rivista:International journal of molecular sciences (Online)/anno:2017/pagina_da:/pagina_a:/intervallo_pagine:/volume:18
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 4; Pages: 891
DOI: 10.3390/ijms18040891
Popis: Scaffold proteins play pivotal roles in the regulation of signaling pathways, integrating external and internal stimuli to various cellular outputs. We report the pattern of cellular and subcellular expression of scaffoldins angiomotin-like 2 (AmotL2), FK506 binding protein 5 (FKBP51) and IQ motif containing GTPase-activating protein 1 (IQGAP1) in colorectal cancer (CRC) and metastases in liver resected after oxaliplatin-based chemotherapy (CT). Positive immunostaining for the three scaffoldins was found in most cells in healthy colon, tumor, healthy liver and metastasized liver. The patterns of expression of AmotL2, FKBP51 and IQGAP1 show the greatest variability in immune system cells and neurons and glia cells and the least in blood vessel cells. The simultaneous subcellular localization in tumor cells and other cell types within the tumor suggest an involvement of these three scaffoldins in cancer biology, including a role in Epithelial Mesenchymal Transition. The display in differential localization and quantitative expression of AmotL2, FKBP51, and IQGAP1 could be used as biomarkers for more accurate tumor staging and as potential targets for anti-cancer therapeutics by blocking or slowing down their interconnecting functions. Tough further research needs to be done in order to improve these assessments.
Databáze: OpenAIRE
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