Marked Arterial Functional Changes in Patients With Arterial Vascular Events Across the Early Adult Lifespan
| Autor: | Gavin R. Norton, Chanel Robinson, Olebogeng H.I. Majane, Taalib Monareng, Andrea Kolkenbeck-Ruh, Angela J. Woodiwiss, Martin Veller, Philanathi Mabena, Ismail Cassimjee, Pinhas Sareli, Girish Modi, Eitzaz Sadiq, Grace Tade, Ferande Peters, Ravi Naran, Nomvuyo Manyatsi, Tshegofatso H Motau, Talib Abdool-Carrim, Vernice R. Peterson |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Aging Arteriosclerosis Black People Blood Pressure 030204 cardiovascular system & hematology Pulse Wave Analysis 03 medical and health sciences South Africa 0302 clinical medicine Vascular Stiffness Ischemia Risk Factors Internal medicine medicine Humans In patient Arterial Pressure 030212 general & internal medicine Stroke Aorta Aged business.industry Extremities Arteries Middle Aged medicine.disease Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 40(6) |
| ISSN: | 1524-4636 |
| Popis: | Objective: The age at which arteriosclerosis begins to contribute to events is uncertain. We determined, across the adult lifespan, the extent to which arteriosclerosis-related changes in arterial function occur in those with precipitous arterial events (stroke and critical limb ischemia). Approaches and Results: In 1082 black South Africans (356 with either critical limb ischemia [n=238] or stroke [n=118; 35.4% premature], and 726 age, sex, and ethnicity-matched randomly selected controls), arterial function was evaluated from applanation tonometry and velocity and diameter measurements in the outflow tract. Compared with age- and sex-matched controls, over 10-year increments in age from 20 to 60years, multivariate-adjusted (including steady-state pressures) aortic pulse wave velocity, characteristic impedance (Zc), forward wave pressures (Pf), and early systolic pulse pressure amplification were consistently altered in those with arterial events. Increases in Zc were accounted for by aortic stiffness (no differences in aortic diameter) and Pf by changes in Zc and not aortic flow or wave re-reflection. Multivariate-adjusted pulse wave velocity (7.48±0.30 versus 5.82±0.15 m/s, P P P P P Conclusions: Arteriosclerosis-related changes in arterial function are consistently associated with arterial events beyond risk factors from as early as 20 years of age. |
| Databáze: | OpenAIRE |
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