Functional MRI (fMRI) evaluation of hyperbaric oxygen therapy (HBOT) efficacy in chronic cerebral stroke: A small retrospective consecutive case series
| Autor: | Simone Bertossi, Daniela Cevolani, Martino Cellerini, Luigi Santarella, Ferruccio Di Donato |
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| Přispěvatelé: | Cevolani D., Di Donato F., Santarella L., Bertossi S., Cellerini M. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Hyperbaric oxygen therapy (HBOT) Health Toxicology and Mutagenesis medicine.medical_treatment Central nervous system lcsh:Medicine Cerebral stroke Blood oxygenation level- dependent (BOLD) signal Brain Ischemia Chronic cerebral stroke 03 medical and health sciences 0302 clinical medicine Hyperbaric oxygen Physical medicine and rehabilitation Oxygen therapy Neuroplasticity medicine otorhinolaryngologic diseases Humans 030212 general & internal medicine Aged Language Retrospective Studies Paresis Hyperbaric Oxygenation Blood Oxygenation Level-Dependent (BOLD) signal medicine.diagnostic_test business.industry Brief Report lcsh:R Public Health Environmental and Occupational Health Consecutive case series Middle Aged Magnetic Resonance Imaging Stroke Functional magnetic resonance imaging (fMRI) medicine.anatomical_structure nervous system medicine.symptom Functional magnetic resonance imaging business psychological phenomena and processes 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 190, p 190 (2021) |
| Popis: | Topics: Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts). Introduction: Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used this Magnetic Resonance (MR) technique for this purpose, till now. Methods: All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms). Results: After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas. Conclusions: These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT. |
| Databáze: | OpenAIRE |
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