Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide
| Autor: | Ronald C. Kennedy, Alan R. Culwell, F. B. Hollinger, Yanuario Sanchez, Joseph L. Melnick, James T. Sparrow, Gordon R. Dreesman, Irina Ionescu-Matiu |
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| Rok vydání: | 1983 |
| Předmět: |
Idiotype
Chemical Phenomena Immunology Peptide Alkylation Biology Antibodies Viral Microbiology Epitope Antigen-Antibody Reactions Epitopes Antigen Immunoglobulin Idiotypes Virology Humans Hepatitis B Antibodies chemistry.chemical_classification Hepatitis B Surface Antigens Molecular biology Cyclic peptide Chemistry chemistry Insect Science Macrophage-1 antigen Peptides Research Article |
| Zdroj: | Journal of virology. 46(2) |
| ISSN: | 0022-538X |
| Popis: | A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide. |
| Databáze: | OpenAIRE |
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