Cerebral venous thrombosis and plasma concentrations of factor VIII and von Willebrand factor: a case control study
| Autor: | Olivier Godefroy, Jean-Marc Bugnicourt, Chantal Lamy, Bertrand Roussel, Blaise Tramier |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Paper congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Cranial Sinuses Thrombophilia Gastroenterology Von Willebrand factor Risk Factors hemic and lymphatic diseases Internal medicine General screening von Willebrand Factor Medicine Humans Risk factor Aged Venous Thrombosis Factor VIII biology business.industry Case-control study Middle Aged medicine.disease Surgery Psychiatry and Mental health Venous thrombosis Cerebrovascular Disorders Case-Control Studies Plasma concentration biology.protein Population study Female Neurology (clinical) business |
| Zdroj: | Journal of neurology, neurosurgery, and psychiatry. 78(7) |
| ISSN: | 1468-330X |
| Popis: | Background: High plasma concentrations of factor VIII (FVIII) and von Willebrand factor (VWF) have been recently associated with a moderately increased risk of venous thrombosis, but their roles in cerebral sinus and venous thrombosis (CSVT) have not been addressed. To determine whether elevation of FVIII and VWF is more frequent in CSVT, we analysed plasma levels of FVIII and VWF in a case control study. Methods: The study population consisted of 25 consecutive patients (of whom nine were excluded) admitted for CSVT to the Department of Neurology, Amiens University Hospital, France, from January 1997 to December 2002, for a general screening for thrombophilia. Sixty-four healthy subjects matched for age and sex formed the group control. Results: Mean FVIII (CSVT: 167.3 (SD 48.8) IU/dl; control group: 117.9 (39.8) IU/dl; p = 0.001) and VWF levels (CSVT: 165.4 (76.5)%; control group: 108.5 (27.8)%; p = 0.01) were significantly higher in the CSVT group. Using the 95th percentile of the control group as the cut off value, elevated FVIII (>190 IU/dl) occurred in 25% (4/16) (p = 0.005) and elevated VWF (>168%) in 37.5% (6/16) of patients with CSVT (p 150 IU/dl or >150%) showed the same results (FVIII: p = 0.005; VWF: p = 0.009). Conclusion: Our study suggests that elevation of plasma factor VIII levels is the most common prothrombotic risk factor for CSVT. Elevation of VWF is also associated with an increased risk of CSVT but its effect seems to be partly mediated through FVIII. |
| Databáze: | OpenAIRE |
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