Boron neutron capture therapy of brain tumors: clinical trials at the Finnish facility using boronophenylalanine
| Autor: | Markus Färkkilä, Martti Kulvik, Johanna Karila, Mikko Tenhunen, Iiro Auterinen, Sauli Savolainen, Juha Jääskeläinen, Juha Laakso, Inkeri Ruokonen, Mika Kortesniemi, Anders Paetau, Heikki Minn, Leena Kankaanranta, Merja Kallio, Petri Kotiluoto, Tom Serén, Päiivi Ryynänen, Eija Järviluoma, Antti Brander, Tiina Seppälä, Heikki Joensuu, Jyrki Vähätalo |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Boron Compounds Male Cancer Research medicine.medical_treatment Boron Neutron Capture Therapy Context (language use) Sodium Borocaptate 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Glioma Humans Medicine Prospective Studies Prospective cohort study Survival rate Finland Aged Boron Brain Neoplasms business.industry Radiotherapy Planning Computer-Assisted Dose-Response Relationship Radiation Radiotherapy Dosage Middle Aged medicine.disease 3. Good health Survival Rate Clinical trial Radiation therapy Clinical research Neurology Oncology 030220 oncology & carcinogenesis Female Neurology (clinical) Neoplasm Recurrence Local Glioblastoma business Nuclear medicine |
| Zdroj: | University of Helsinki |
| ISSN: | 1573-7373 0167-594X |
| Popis: | Two clinical trials are currently running at the Finnish dedicated boron neutron capture therapy (BNCT) facility. Between May 1999 and December 2001, 18 patients with supratentorial glioblastoma were treated with boronophenylalanine (BPA)-based BNCT within a context of a prospective clinical trial (protocol P-01). All patients underwent prior surgery, but none had received conventional radiotherapy or cancer chemotherapy before BNCT. BPA-fructose was given as 2-h infusion at BPA-dosages ranging from 290 to 400 mg/kg prior to neutron beam irradiation, which was given as a single fraction from two fields. The average planning target volume dose ranged from 30 to 61 Gy (W), and the average normal brain dose from 3 to 6 Gy (W). The treatment was generally well tolerated, and none of the patients have died during the first months following BNCT. The estimated 1-year overall survival is 61%. In another trial (protocol P-03), three patients with recurring or progressing glioblastoma following surgery and conventional cranial radiotherapy to 50-60 Gy, were treated with BPA-based BNCT using the BPA dosage of 290 mg/kg. The average planning target dose in these patients was 25-29 Gy (W), and the average whole brain dose 2-3 Gy (W). All three patients tolerated brain reirradiation with BNCT, and none died during the first three months following BNCT. We conclude that BPA-based BNCT has been relatively well tolerated both in previously irradiated and unirradiated glioblastoma patients. Efficacy comparisons with conventional photon radiation are difficult due to patient selection and confounding factors such as other treatments given, but the results support continuation of clinical research on BPA-based BNCT. |
| Databáze: | OpenAIRE |
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