Selective obstruction of the mTORC2 complex by a naturally occurring cholestane saponin (OSW-1) for inhibiting prostate cancer cell growth
| Autor: | Ahmed Elgehama |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Saponin Pharmaceutical Science mTORC1 Mechanistic Target of Rapamycin Complex 2 mTORC2 Analytical Chemistry Prostate cancer chemistry.chemical_compound Drug Discovery medicine Cytotoxic T cell Humans PI3K/AKT/mTOR pathway Cholestenones Pharmacology chemistry.chemical_classification Natural product Cholestanes Molecular Structure business.industry TOR Serine-Threonine Kinases Organic Chemistry Prostatic Neoplasms General Medicine Saponins medicine.disease Complementary and alternative medicine chemistry Cancer research Molecular Medicine Cholestane Ornithogalum business |
| Zdroj: | Journal of Asian natural products research. 24(7) |
| ISSN: | 1477-2213 |
| Popis: | Ornithogalum caudatum Ait (OCA) is a natural product used in Chinese traditional medicine. The cholestane saponin OSW-1 is isolated from plant OCA and has recently been shown to have potent cytotoxic effects against different types of cancers. The therapeutic efficacy of OSW-1 on prostate cancer and its underlying mechanism are yet to be established. OSW-1 inhibited the growth of prostate cancer cells by interrupting the interaction between mTOR and Rictor/mTORC2. This mechanism showed a better therapeutic outcome than that of the conventional inhibition of mTOR and provided a basis for as sisting modern prostate cancer treatment strategies. |
| Databáze: | OpenAIRE |
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