Glomerular filtration rate by single-injection inulin clearance: definition of a workable protocol for children
| Autor: | J. C. M. Hendriks, Dorine W. Swinkels, J. Nauta, M. C. J. W. De Jong |
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| Rok vydání: | 2000 |
| Předmět: |
Methodologie van interventieonderzoek
medicine.medical_specialty Adolescent Urinary system Clinical Biochemistry Inulin Urology Renal function Ontwikkeling en kwaliteitsborging in de laboratoriumgeneeskunde Innovation and Quality assurance in laboratory medicine chemistry.chemical_compound Methodology of intervention research Predictive Value of Tests Internal medicine medicine Humans Child Inulin Clearance urogenital system Clinical Laboratory Techniques OVERIG ONDERZOEK MIES Infant General Medicine Single injection Laboratories Hospital Endocrinology chemistry Child Preschool Serum clearance Glomerular Filtration Rate |
| Zdroj: | Annals of Clinical Biochemistry, 37, pp. 60-66 Annals of Clinical Biochemistry, 37, 60-66 |
| ISSN: | 0004-5632 |
| Popis: | The total serum clearance of inulin after a single intravenous injection is an established method for the determination of the glomerular filtration rate (GFR). To optimize this procedure in children, we analysed 117 serum inulin time-decay curves in 59 children (age range 1·3-15·2 years) with renal disease. It was found that the two-compartment model fitted statistically better to the disappearance curves of serum inulin than the one-compartment model. The sampling frequency could be reduced from 12 to a minimum of seven data points (t = 0, 10, 20, 30, 65, 120 and 240 min) in 4 h without a relevant change in the fit of the two-compartment model to the data or in the calculated clearance of serum inulin. We conclude that, by using a standardized 'seven-sample schedule', followed by a two-compartment analysis, the single-injection serum clearance of inulin is a suitable compromise between practical convenience and clinical accuracy for the determination of the GFR in children. |
| Databáze: | OpenAIRE |
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