Anti-inflammatory Effects of a Sesquiterpene Lactone Extract from Chicory (Cichorium intybus L.) Roots
| Autor: | Moul Dey, Christophe Ripoll, Anvar G. Kurmukov, Barbara M. Schmidt, Nebojša Ilić, Ilya Raskin, Alexander Poulev |
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| Rok vydání: | 2007 |
| Předmět: |
Pharmacology
chemistry.chemical_classification biology Traditional medicine 010405 organic chemistry Chemistry medicine.drug_class Inflammation Plant Science General Medicine biology.organism_classification Sesquiterpene lactone Sesquiterpene 01 natural sciences Anti-inflammatory 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Complementary and alternative medicine Cichorium Edema Drug Discovery medicine Chicory root extract medicine.symptom |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1555-9475 1934-578X |
| DOI: | 10.1177/1934578x0700200702 |
| Popis: | A chicory root extract rich in sesquiterpene lactones significantly reduced inflammation in two animal models. In a rat paw edema model, chicory extract at 50 and 100 mg/kg significantly reduced inflammation by 58 and 76%, respectively, 24 h after carrageenan injection. In a mouse collagen induced arthritis model, chicory extract (200 mg/kg) reduced paw edema by 71% while the extract was being administered, and 31% 48 h after extract administration was discontinued. Two possible modes of action were investigated, pro-inflammatory gene expression and nitric oxide production by LPS-elicited macrophages. Chicory root extract down-regulated COX-2, TNF-α, IL1β, and iNOS expression and reduced nitric oxide production in a dose dependant manner. Several compounds were isolated from the chicory extract and tested in vitro to confirm activity. Dihydrolactucopicrin and 8-deoxylactucin showed particularly high nitric oxide inhibitory activity (IC50 = 13 μM for both). Dihydrolactucopicrin also was shown to down-regulate pro-inflammatory gene expression. These data demonstrate that chicory extracts rich in sesquiterpene lactones have potent anti-inflammatory activity with potential therapeutic use. |
| Databáze: | OpenAIRE |
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