Coronary microvascular dysfunction in diabetes mellitus
| Autor: | Ivica Bošnjak, Tatjana Bačun, Mario Gros, Kristina Selthofer-Relatić, Ines Drenjančević, Dijana Kibel, Aleksandar Kibel |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Cardiomyopathy 030209 endocrinology & metabolism Coronary microcirculation 030204 cardiovascular system & hematology Biochemistry endothelial dysfunction Microcirculation 03 medical and health sciences Diabetes mellitus 0302 clinical medicine nitric oxide Internal medicine medicine Humans Endothelial dysfunction Pathological coronary microvascular dysfunction business.industry arachidonic acid metabolites Biochemistry (medical) Special Issue: The Role of Vascular Dysfunction in Disease and Therapy artery Cell Biology General Medicine Blood flow medicine.disease Coronary Vessels medicine.anatomical_structure Microvessels Cardiology Diabetes mellitus coronary microvascular dysfunction microcirculation endothelial dysfunction cardiomyopathy artery nitric oxide arachidonic acid metabolites Endothelium Vascular business cardiomyopathy Algorithms Artery |
| Zdroj: | The Journal of International Medical Research |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/0300060516675504 |
| Popis: | The significance, mechanisms and consequences of coronary microvascular dysfunction associated with diabetes mellitus are topics into which we have insufficient insight at this time. It is widely recognized that endothelial dysfunction that is caused by diabetes in various vascular beds contributes to a wide range of complications and exerts unfavorable effects on microcirculatory regulation. The coronary microcirculation is precisely regulated through a number of interconnected physiological processes with the purpose of matching local blood flow to myocardial metabolic demands. Dysregulation of this network might contribute to varying degrees of pathological consequences. This review discusses the most important findings regarding coronary microvascular dysfunction in diabetes from pre-clinical and clinical perspectives. |
| Databáze: | OpenAIRE |
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