Alterations in T and B cell function persist in convalescent COVID-19 patients
| Autor: | Halima A. Shuwa, Tovah N. Shaw, Sean B. Knight, Kelly Wemyss, Flora A. McClure, Laurence Pearmain, Ian Prise, Christopher Jagger, David J. Morgan, Saba Khan, Oliver Brand, Elizabeth R. Mann, Andrew Ustianowski, Nawar Diar Bakerly, Paul Dark, Christopher E. Brightling, Seema Brij, Timothy Felton, Angela Simpson, John R. Grainger, Tracy Hussell, Joanne E. Konkel, Madhvi Menon, Rohan Ahmed, Miriam Avery, Katharine Birchall, Evelyn Charsley, Alistair Chenery, Christine Chew, Richard Clark, Emma Connolly, Karen Connolly, Simon Dawson, Laura Durrans, Hannah Durrington, Jasmine Egan, Kara Filbey, Claire Fox, Helen Francis, Miriam Franklin, Susannah Glasgow, Nicola Godfrey, Kathryn J. Gray, Seamus Grundy, Jacinta Guerin, Pamela Hackney, Chantelle Hayes, Emma Hardy, Jade Harris, Anu John, Bethany Jolly, Verena Kästele, Gina Kerry, Sylvia Lui, Lijing Lin, Alex G. Mathioudakis, Joanne Mitchell, Clare Moizer, Katrina Moore, Stuart Moss, Syed Murtuza Baker, Rob Oliver, Grace Padden, Christina Parkinson, Michael Phuycharoen, Ananya Saha, Barbora Salcman, Nicholas A. Scott, Seema Sharma, Jane Shaw, Joanne Shaw, Elizabeth Shepley, Lara Smith, Simon Stephan, Ruth Stephens, Gael Tavernier, Rhys Tudge, Louis Wareing, Roanna Warren, Thomas Williams, Lisa Willmore, Mehwish Younas |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
media_common.quotation_subject
Lymphocyte medicine.medical_treatment Translation to patients T cells Disease CD8-Positive T-Lymphocytes Immune system medicine Cytotoxic T cell Humans long COVID B cell media_common B cells business.industry Interleukin-6 SARS-CoV-2 Convalescence COVID-19 General Medicine Clinical and Translational Report Interleukin-10 medicine.anatomical_structure Cytokine Immunology Cytokines viral infection convalescent patients business CD8 |
| Zdroj: | Shuwa, H A, Shaw, T N, Knight, S B, Wemyss, K, McClure, F A, Pearmain, L, Prise, I, Jagger, C, Morgan, D J, Khan, S, Brand, O, Mann, E R, Ustianowski, A, Bakerly, N D, Dark, P, Brightling, C E, Brij, S, Felton, T, Simpson, A, Grainger, J R, Hussell, T, Konkel, J E & Menon, M 2021, ' Alterations in T and B cell function persist in convalescent COVID-19 patients ', Med, vol. 2, no. 6, pp. 720-735.E4 . https://doi.org/10.1016/j.medj.2021.03.013 Shuwa, H A, Shaw, T, Knight, S, Wemyss, K, Mcclure, F, Pearmain, L, Prise, I, Jagger, C, Morgan, D, Khan, S, Brand, O, Mann, E, Ustianowski, A, Diar Bakerly, N, Dark, P, Brightling, C E, Brij, S, Felton, T, Simpson, A, Grainger, J, Hussell, T, Konkel, J & Menon, M 2021, ' Alterations in T and B cell function persist in convalescent COVID-19 patients ', Med, vol. 2, no. 6, pp. 720-+ . https://doi.org/10.1016/j.medj.2021.03.013 Med (New York, N.y.) |
| DOI: | 10.1016/j.medj.2021.03.013 |
| Popis: | Background Emerging studies indicate that some COVID-19 patients suffer from persistent symptoms including breathlessness and chronic fatigue; however the long-term immune response in these patients presently remains ill-defined. Methods Here we describe the phenotypic and functional characteristics of B and T cells in hospitalised COVID-19 patients during acute disease and at 3-6 months of convalescence. Findings We report that the alterations in B cell subsets observed in acute COVID-19 patients were largely recovered in convalescent patients. In contrast, T cells from convalescent patients displayed continued alterations with persistence of a cytotoxic programme evident in CD8+ T cells as well as elevated production of type-1 cytokines and IL-17. Interestingly, B cells from patients with acute COVID-19 displayed an IL-6/IL-10 cytokine imbalance in response to toll-like receptor activation, skewed towards a pro-inflammatory phenotype. Whereas the frequency of IL-6+ B cells was restored in convalescent patients irrespective of clinical outcome, recovery of IL-10+ B cells was associated with resolution of lung pathology. Conclusions Our data detail lymphocyte alterations in previously hospitalized COVID-19 patients up to 6 months following hospital discharge and identify 3 subgroups of convalescent patients based on distinct lymphocyte phenotypes, with one subgroup associated with poorer clinical outcome. We propose that alterations in B and T cell function following hospitalisation with COVID-19 could impact longer term immunity and contribute to some persistent symptoms observed in convalescent COVID-19 patients. Funding Provided by UKRI, Lister Institute of Preventative Medicine, The Wellcome Trust, The Kennedy Trust for Rheumatology Research and 3M Global Giving. Graphical Abstract Shuwa et al examine lymphocyte characteristics in acute and convalescent COVID-19 patients, detailing persistent alterations in lymphocyte phenotype up to 6 months following hospital discharge. In this report they identify 3 subgroups of convalescent patients based on distinct lymphocyte signatures, with one subgroup associated with poorer clinical outcome. |
| Databáze: | OpenAIRE |
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