Resistin is associated with mortality in patients with traumatic brain injury
| Autor: | Fang-Long Zhu, Qing-Wei Lv, Hang-Bin Huang, Song-Bin Yang, Guo-Hai Zhang, Xiao-Qiao Dong |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent endocrine system diseases Traumatic brain injury Disease outcome Critical Care and Intensive Care Medicine Young Adult Internal medicine medicine Humans Glasgow Coma Scale Resistin In patient Young adult Child Aged Aged 80 and over Intracerebral hemorrhage business.industry Research nutritional and metabolic diseases Middle Aged respiratory system medicine.disease Peripheral blood Surgery Brain Injuries Female sense organs business Biomarkers hormones hormone substitutes and hormone antagonists |
| Zdroj: | Critical Care |
| ISSN: | 1364-8535 |
| DOI: | 10.1186/cc9307 |
| Popis: | Introduction Recently, we reported that high levels of resistin are present in the peripheral blood of patients with intracerebral hemorrhage and are associated with a poor outcome. However, not much is known regarding the change in plasma resistin and its relation with mortality after traumatic brain injury (TBI). Thus, we sought to investigate change in plasma resistin level after TBI and to evaluate its relation with disease outcome. Methods Fifty healthy controls and 94 patients with acute severe TBI were included. Plasma samples were obtained on admission and at days 1, 2, 3, 5 and 7 after TBI. Its concentration was measured by enzyme-linked immunosorbent assay. Results Twenty-six patients (27.7%) died from TBI within 1 month. After TBI, plasma resistin level in patients increased during the 6-hour period immediately after TBI, peaked within 24 hours, plateaued at day 2, decreased gradually thereafter and was substantially higher than that in healthy controls during the 7-day period. A forward stepwise logistic regression selected plasma resistin level (odds ratio, 1.107; 95% confidence interval, 1.014-1.208; P = 0.023) as an independent predictor for 1-month mortality of patients. A multivariate linear regression showed that plasma resistin level was negatively associated with Glasgow Coma Scale score (t = -6.567, P < 0.001). A receiver operating characteristic curve identified plasma resistin cutoff level (30.8 ng/mL) that predicted 1-month mortality with the optimal sensitivity (84.6%) and specificity (75.0%) values (area under curve, 0.854; 95% confidence interval, 0.766-0.918; P < 0.001). Conclusions Increased plasma resistin level is found and associated with Glasgow Coma Scale score and mortality after TBI. |
| Databáze: | OpenAIRE |
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