The Opportunities of Metabolomics in Drug Safety Evaluation
| Autor: | Amina I. Shehu, Pengcheng Wang, Xiaochao Ma |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology Drug Evaluation system Drug candidate media_common.quotation_subject Pharmacology toxicology Computational biology Biology Biochemistry Article Clinical Practice 03 medical and health sciences 030104 developmental biology Metabolomics Drug Discovery Genetics Drug toxicity Drug metabolism media_common |
| Zdroj: | Current Pharmacology Reports. 3:10-15 |
| ISSN: | 2198-641X |
| DOI: | 10.1007/s40495-016-0079-5 |
| Popis: | Although safety of drug candidates is carefully monitored in preclinical and clinical studies using a variety of approaches, drug toxicity may still occur in clinical practice. Therefore, novel approaches are needed to complement the current drug safety evaluation system. Metabolomics comprehensively analyzes the metabolites altered by drug exposure, which can therefore be used to profile drug metabolism, endobiotic metabolism, and drug-microbiota interactions. The information from metabolomic analysis can be used to determine the off-targets of a drug candidate, and thus provide a mechanistic understanding of drug toxicity. We herein discuss the opportunities of metabolomics in drug safety evaluation. |
| Databáze: | OpenAIRE |
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