The antinociceptive effects of epidural opiates in the cat: Studies on the pharmacology and the effects of lipophilicity in spinal analgesia
| Autor: | Tony L. Yaksh, Alfred S. Tung |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Epidural Space
Male Narcotics Time Factors Meperidine Analgesic Pain (+)-Naloxone Pharmacology Reflex Animals Medicine Epidural administration Skin Dose-Response Relationship Drug Morphine Naloxone business.industry Nociceptors Lipids Epidural space Fentanyl Anesthesiology and Pain Medicine Nociception medicine.anatomical_structure Neurology Mechanism of action Anesthesia Cats Female Neurology (clinical) medicine.symptom business Methadone medicine.drug |
| Zdroj: | Pain. 12:343-356 |
| ISSN: | 0304-3959 |
| DOI: | 10.1016/0304-3959(82)90179-8 |
| Popis: | In cats implanted chronically with catheters in the lumbar epidural space, the pharmacology of the analgesia of 4 opiates, which varied widely in their physicochemical properties, was studied. Results revealed the following order of epidural analgesic potency as indicated by suppression of the spinally mediate skin twitch reflex: lofentanyl greater than morphine greater than L-methadone greater than meperidine greater than D-methadone. With the doses used in these experiments the duration of action was: morphine greater than lofentanyl greater than L-methadone = meperidine. In addition, antagonism of these effects by systemic naloxone and the development of tolerance after daily epidural administration of morphine were demonstrated. These data, jointly, indicate a specific receptor mechanism of action. We suggest that this animal model may be useful for the evaluation of new opiates and non-opiates to be given via the epidural route. |
| Databáze: | OpenAIRE |
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