Asian Versus Non-Asian Outcomes in Nasopharyngeal Carcinoma: A North American Population-based Analysis
| Autor: | Yongliang Zhai, Cheryl Ho, Janessa Laskin, Sarah Hamilton, Paul Mak, Jonn Wu |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Oncology Cancer Research Kaplan-Meier Estimate Cohort Studies 0302 clinical medicine Antineoplastic Combined Chemotherapy Protocols 030212 general & internal medicine education.field_of_study Nasopharyngeal Carcinoma Hazard ratio Chemoradiotherapy Middle Aged Prognosis Combined Modality Therapy Treatment Outcome 030220 oncology & carcinogenesis Female Cohort study Adult medicine.medical_specialty Population Disease-Free Survival White People 03 medical and health sciences Asian People Internal medicine medicine Humans Neoplasm Invasiveness education Survival analysis Aged Neoplasm Staging Proportional Hazards Models Retrospective Studies British Columbia Performance status business.industry Proportional hazards model Carcinoma Nasopharyngeal Neoplasms Retrospective cohort study medicine.disease Survival Analysis Nasopharyngeal carcinoma Multivariate Analysis Radiotherapy Conformal business |
| Zdroj: | American Journal of Clinical Oncology. 39:575-580 |
| ISSN: | 0277-3732 |
| Popis: | OBJECTIVES The effect of ethnicity on nasopharyngeal cancer (NPC) outcomes is unclear. This retrospective analysis examines survival and the impact of concurrent chemoradiation (chemoRT) among Asian and non-Asian patients. METHODS Subjects included 380 consecutive patients with NPC treated at a Canadian institution from 2000 to 2009. Five-year Kaplan-Meier progression-free survival (PFS), disease-specific survival (DSS), and overall survival (OS) were compared between Asian (n=279) and non-Asian (n=101) subjects. Multivariable analysis was performed using Cox regression modeling. Two-variable interaction terms with concurrent chemoRT were used to examine whether concurrent chemoRT conferred different effects among subgroups. RESULTS Asian subjects presented with earlier stage (P=0.005), were younger, had better performance status, and were less likely smokers (all P |
| Databáze: | OpenAIRE |
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