Candidate genes linking maternal nutrient exposure to offspring health via DNA methylation: a review of existing evidence in humans with specific focus on one-carbon metabolism
| Autor: | Fall Chd, Philip T. James, Prachand Issarapu, Dilip K. Yadav, Smeeta Shrestha, Lovejeet Kaur, Ashutosh Singh Tomar, Sara Sajjadi, Matt J. Silver, Giriraj R. Chandak, Karen A. Lillycrop, Ayden Saffari, Andrew M. Prentice |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Candidate gene Epidemiology Offspring growth Developmental Origins of Health and Disease Computational biology Biology Epigenesis Genetic 03 medical and health sciences Pregnancy Humans Epigenetics Gene metastable epialleles DNA methylation Maternal Nutritional Physiological Phenomena Nutrients General Medicine Epigenome one-carbon metabolism Carbon Diet fetal programming 030104 developmental biology Gene Expression Regulation cardiometabolic outcomes Female candidate genes Candidate Disease Gene Genomic imprinting cognitive development |
| Zdroj: | International Journal of Epidemiology |
| ISSN: | 1464-3685 0300-5771 |
| Popis: | BackgroundMounting evidence suggests that nutritional exposures during pregnancy influence the fetal epigenome, and that these epigenetic changes can persist postnatally, with implications for disease risk across the life course.MethodsWe review human intergenerational studies using a three-part search strategy. Search 1 investigates associations between preconceptional or pregnancy nutritional exposures, focusing on one-carbon metabolism, and offspring DNA methylation. Search 2 considers associations between offspring DNA methylation at genes found in the first search and growth-related, cardiometabolic and cognitive outcomes. Search 3 isolates those studies explicitly linking maternal nutritional exposure to offspring phenotype via DNA methylation. Finally, we compile all candidate genes and regions of interest identified in the searches and describe their genomic locations, annotations and coverage on the Illumina Infinium Methylation beadchip arrays.ResultsWe summarize findings from the 34 studies found in the first search, the 31 studies found in the second search and the eight studies found in the third search. We provide details of all regions of interest within 45 genes captured by this review.ConclusionsMany studies have investigated imprinted genes as priority loci, but with the adoption of microarray-based platforms other candidate genes and gene classes are now emerging. Despite a wealth of information, the current literature is characterized by heterogeneous exposures and outcomes, and mostly comprise observational associations that are frequently underpowered. The synthesis of current knowledge provided by this review identifies research needs on the pathway to developing possible early life interventions to optimize lifelong health. |
| Databáze: | OpenAIRE |
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