Cannabinoids reveal importance of spike timing coordination in hippocampal function
| Autor: | Alexander Thome, György Buzsáki, David Robbe, Sean M. Montgomery, Bruce L. McNaughton, Pavel E. Rueda-Orozco |
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| Rok vydání: | 2006 |
| Předmět: |
Periodicity
Cannabinoid receptor Population Action Potentials Hippocampus Local field potential Neuroscientist Phenols Cyclohexanes medicine Animals Memory impairment Dronabinol Cortical Synchronization Theta Rhythm Receptors Cannabinoid education Systems neuroscience education.field_of_study Cannabinoids General Neuroscience Cyclohexanols Rats medicine.anatomical_structure nervous system Neuron Psychology Neuroscience |
| Zdroj: | Nature Neuroscience. 9:1526-1533 |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/nn1801 |
| Popis: | Cannabinoids impair hippocampus-dependent memory in both humans and animals, but the network mechanisms responsible for this effect are unknown. Here we show that the cannabinoids Delta(9)-tetrahydrocannabinol and CP55940 decreased the power of theta, gamma and ripple oscillations in the hippocampus of head-restrained and freely moving rats. These effects were blocked by a CB1 antagonist. The decrease in theta power correlated with memory impairment in a hippocampus-dependent task. By simultaneously recording from large populations of single units, we found that CP55940 severely disrupted the temporal coordination of cell assemblies in short time windows (100 ms) yet only marginally affected population firing rates of pyramidal cells and interneurons. The decreased power of local field potential oscillations correlated with reduced temporal synchrony but not with firing rate changes. We hypothesize that reduced spike timing coordination and the associated impairment of physiological oscillations are responsible for cannabinoid-induced memory deficits. |
| Databáze: | OpenAIRE |
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