Geometric Analysis of Type B Aortic Dissections Shows Aortic Remodeling After Intervention Using Multilayer Stents
| Autor: | Horatiu Moldovan, Jorn P. Meekel, Cristian Bucurenciu, Kak K. Yeung, Anca M. Chitic, Gabriela Candea, Crina Solomon, Tatiana Melnic, Victor S Costache, Andreea Costache, Iulian Vasile Antoniac |
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| Přispěvatelé: | Surgery, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, Academic Medical Center |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Materials science
Geometric analysis Hemodynamics 3d model computational fluid dynamics 030204 cardiovascular system & hematology lcsh:Technology Article 03 medical and health sciences 0302 clinical medicine medicine Medical imaging General Materials Science aortic dissection lcsh:Microscopy lcsh:QC120-168.85 Aortic dissection lcsh:QH201-278.5 multilayer flow modulator lcsh:T medicine.disease aortic remodeling geometric analysis Lumen Diameter Flow velocity lcsh:TA1-2040 lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 030217 neurology & neurosurgery Biomedical engineering Lumen (unit) |
| Zdroj: | Materials Volume 13 Issue 10 Materials, Vol 13, Iss 2274, p 2274 (2020) Materials, 13(10):2274. MDPI AG Costache, V S, Meekel, J P, Costache, A, Melnic, T, Solomon, C, Chitic, A M, Bucurenciu, C, Moldovan, H, Antoniac, I, Candea, G & Yeung, K K 2020, ' Geometric analysis of type b aortic dissections shows aortic remodeling after intervention using multilayer stents ', Materials, vol. 13, no. 10, 2274 . https://doi.org/10.3390/ma13102274 |
| ISSN: | 1996-1944 |
| DOI: | 10.3390/ma13102274 |
| Popis: | Recently, multilayer stents for type B aortic dissections (TBAD) have been proposed to decrease false lumen flow, increase and streamline true lumen flow, and retain branch vessel patency. We aimed to provide a protocol with standardized techniques to investigate aortic remodeling of TBAD by multilayer flow modulators (MFM) in static geometric and hemodynamic analyses. Combining existing literature and new insights, a standardized protocol was designed. Using pre- and postoperative CT scans, geometric models were constructed, lumen dimensions were calculated, computational fluid dynamics (CFD) models were composed, and velocity and pressures were calculated. Sixteen TBAD cases treated with MFM were included for analysis. For each case, aortic remodeling was analyzed using post-processing medical imaging software. After 3D models were created, geometrical anatomical measurements were performed, and meshes for finite element analysis were generated. MFM cases were compared pre- and postoperatively true lumen volumes increased (p < 0.001), false lumen volumes decreased (p = 0.001), true lumen diameter at the plane of maximum compression (PMC) increased (p < 0.001), and false lumen index decreased (p = 0.008). True lumen flow was streamlined, and the overall fluid velocity and pressures decreased (p < 0.001 and p = 0.006, respectively). This protocol provided a standardized method to evaluate the effects of MFM treatments in TBAD on geometric analyses, PMC, and CFD outcomes. |
| Databáze: | OpenAIRE |
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