Beyond mineralisation: metabolic functions for matrix mineralisation regulators
| Autor: | Colin Farquharson, Vicky E MacRae, Fiona Roberts, Scott Dillon, Greg R. Markby |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Biomineralization
0301 basic medicine medicine.medical_specialty Phosphoric Diester Hydrolases Endocrinology Diabetes and Metabolism Druggability 030209 endocrinology & metabolism Disease Area of interest Biology Matrix (biology) Bioinformatics Phosphoric Monoester Hydrolases Skeletal tissue 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Endocrinology Metabolic Diseases Internal medicine medicine Animals Humans |
| Zdroj: | Journal of Endocrinology. 245:R11-R22 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1530/joe-19-0460 |
| Popis: | The physiological mineralisation of skeletal tissues, as well as the pathological mineralisation of soft tissues involves a fine balance between regulators that either promote or inhibit the process. In recent years, several studies have advocated a non-skeletal role for some of these mineralisation regulators in a range of human diseases, including diabetes, cardiovascular disease, obesity and neurodegenerative disease. This is an emerging area of interest and the functional roles and mechanisms of action of these various endocrine factors, phosphatases and phosphodiesterase’s in important pathologies are the focus of this review. Mechanistic insight of the pathways through which these acknowledged regulators of skeletal mineralisation act beyond the skeleton has the potential to identify druggable targets for commonly experienced morbidities, notably those related to metabolism and metabolic syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|