Movement Disorders and Mortality in Severely Mentally Ill Patients
| Autor: | Anne E Willems, Charlotte L Mentzel, Pieter Roberto Bakker, Jim Van Os, Diederik E Tenback, Petra Gelan, Erna Daantjes, Glenn E Matroos, Hans W Hoek, Peter N Van Harten |
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| Přispěvatelé: | RS: MHeNs - R2 - Mental Health, Psychiatry 3, Psychiatrie & Neuropsychologie |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Dyskinesia
Drug-Induced CARIBBEAN PATIENTS DYSTONIA LONG-TERM Theme: Motor symptoms are important for identifying understanding and treating serious mental illness ANTIPSYCHOTIC TREATMENT TARDIVE-DYSKINESIA Curacao Syndrome survival schizophrenia Psychiatry and Mental health Basal Ganglia Diseases Parkinsonian Disorders Mentally Ill Persons Tardive dyskinesia life expectancy Humans RATING-SCALE FOLLOW-UP akathisia Psychomotor Agitation PARKINSON DISEASE parkinsonism Antipsychotic Agents |
| Zdroj: | Schizophr Bull Schizophrenia Bulletin, 48(4), 766-773. Oxford University Press Schizophrenia Bulletin, 48(4):sbac037, 766-773. Oxford University Press |
| ISSN: | 0586-7614 |
| Popis: | Background and Hypothesis There is a substantial gap in life expectancy between patients with severe mental illness (SMI) and the general population and it is important to understand which factors contribute to this difference. Research suggests an association between tardive dyskinesia (TD) and mortality; however, results are inconclusive. In addition, studies investigating associations between parkinsonism or akathisia and mortality are rare. We hypothesized that TD would be a risk factor for mortality in patients with SMI. Study Design We studied a cohort of 157 patients diagnosed predominantly with schizophrenia on the former Netherlands Antilles. TD, parkinsonism, and akathisia were assessed with rating scales on eight occasions over a period of 18 years. Twenty-four years after baseline, survival status and if applicable date of death were determined. Associations between movement disorders and survival were analyzed using Cox regression. Sex, age, antipsychotics, antidepressants and benzodiazepines at each measurement occasion were tested as covariates. Study Results Parkinsonism was a significant risk factor with an HR of 1.02 per point on the motor subscale of the Unified Parkinson’s Disease Rating Scale (range 0–56). TD and akathisia were not significantly associated with mortality. Conclusions Parkinsonism may be an important risk factor for mortality in SMI patients. This finding calls for more follow-up and intervention studies to confirm this finding and to explore whether treatment or prevention of parkinsonism can reduce excess mortality. |
| Databáze: | OpenAIRE |
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