Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?
| Autor: | Fränzel J.B. van Duijnhoven, Harm van Baar, Henk K. van Halteren, Dieuwertje E. Kok, Bibi M.E. Hansson, Lieve van Brakel, Robert B. Beelman, Anne J.M.R. Geijsen, Moniek van Zutphen, Evertine Wesselink, Renate M. Winkels, Dongxiao Sun, Ellen Kampman, John P. Richie |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Cancer Research medicine.medical_specialty Nutrition and Disease Colorectal cancer medicine.medical_treatment Medicine (miscellaneous) Antineoplastic Agents Gastroenterology Severity of Illness Index Antioxidants 03 medical and health sciences chemistry.chemical_compound Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14] 0302 clinical medicine Quality of life Internal medicine Surveys and Questionnaires Voeding en Ziekte Severity of illness medicine Prevalence Humans Life Science Whole blood Aged VLAG Chemotherapy 030109 nutrition & dietetics Nutrition and Dietetics business.industry Ergothioneine Peripheral Nervous System Diseases Middle Aged medicine.disease Peripheral Peripheral neuropathy Oncology chemistry 030220 oncology & carcinogenesis Linear Models Quality of Life Female business Colorectal Neoplasms |
| Zdroj: | Nutrition and Cancer 72 (2020) 3 Nutrition and Cancer-An International Journal, 72, 3, pp. 451-459 Nutrition and Cancer-An International Journal, 72, 451-459 Nutrition and Cancer, 72(3), 451-459 |
| ISSN: | 0163-5581 |
| Popis: | Contains fulltext : 218303.pdf (Publisher’s version ) (Open Access) Objective: Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN) is highly prevalent among colorectal cancer (CRC) patients. Ergothioneine (ET) - a dietary antioxidant -protected against CIPN in experimental models, but human studies are lacking. We explored whether whole blood ET levels were associated with chronic peripheral neuropathy among CRC patients who had completed chemotherapy.Methods: At diagnosis, median ET-concentration in whole blood of 159 CRC patients was 10.2 mug/ml (7.2-15.8). Patients completed questionnaires on peripheral neuropathy 6 months after completion of chemotherapy. We calculated prevalence ratios (PR) to assess associations of ET-concentrations and prevalence of peripheral neuropathy and used linear regression to assess associations with severity of peripheral neuropathy.Results: Prevalence of total and sensory peripheral neuropathy were both 81%. Higher ET-concentrations tended to be associated with lower prevalence of total and sensory peripheral neuropathy, but not statistically significant (highest versus lowest tertile of ET: PR = 0.93(0.78, 1.11) for total neuropathy, and PR = 0.84(0.70, 1.02) for sensory neuropathy). ET-concentrations were not associated with severity of neuropathy.Conclusion: Statistically significant associations were not observed, possibly because of limited sample size. Although data may putatively suggest higher levels of ET to be associated with a lower prevalence of neuropathy, analyses should be repeated in larger populations with larger variability in ET-concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|