Hematogones: a review and update
| Autor: | Foxwell Emmons, Govind Bhagat, Bachir Alobeid, Deborah W. Sevilla, Adriana I. Colovai |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Cancer Research B-Lymphocytes business.industry Stem Cells Bone Marrow Cells Cell Differentiation Hematology Cell lineage Flow Cytometry Precursor B-Cells Gene Expression Regulation Neoplastic Phenotype Oncology Antigens CD Immunology Medicine Animals Humans Cell Lineage Female business Neuroscience |
| Zdroj: | Leukemialymphoma. 51(1) |
| ISSN: | 1029-2403 |
| Popis: | Our knowledge regarding the nature and function of 'hematogones' has evolved considerably, since the initial description more than 70 years ago. Once considered the 'mystery cells' of the bone marrow, major advances in immunology and flow cytometry have enabled us to better characterize these cells and recognize them as physiologic precursors of B-cells. In this review, we describe the morphologic and phenotypic characteristics and clinical relevance of hematogones, and report recent advances in our understanding and knowledge of these cells as they relate to physiologic and different pathologic conditions. |
| Databáze: | OpenAIRE |
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