Cyclical fate restriction: a new view of neural crest cell fate specification
| Autor: | Vsevolod J. Makeev, Robert N. Kelsh, Karen Camargo Sosa, Saeed Farjami, Andrea Rocco, Jonathan H.P. Dawes |
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| Rok vydání: | 2022 |
| Předmět: |
Epithelial-Mesenchymal Transition
Pigment cell Pigmentation Gene Expression Regulation Developmental Neural crest cell fate specification Cell Differentiation Biology Zebrafish Proteins Fate specification Melanocyte Neural Crest Animals Melanocytes Cell Lineage Neuroscience Molecular Biology Neural crest cell Zebrafish Developmental Biology |
| Zdroj: | Kelsh, R N, Sosa, K C, Farjami, S, Makeev, V, Dawes, J H P & Rocco, A 2021, ' Cyclical fate restriction : A new view of neural crest cell fate specification ', Development (Cambridge), vol. 148, no. 22, dev176057 . https://doi.org/10.1242/dev.176057 |
| ISSN: | 1477-9129 |
| Popis: | Neural crest cells are crucial in development, not least because of their remarkable multipotency. Early findings stimulated two hypotheses for how fate specification and commitment from fully multipotent neural crest cells might occur, progressive fate restriction (PFR) and direct fate restriction, differing in whether partially restricted intermediates were involved. Initially hotly debated, they remain unreconciled, although PFR has become favoured. However, testing of a PFR hypothesis of zebrafish pigment cell development refutes this view. We propose a novel ‘cyclical fate restriction’ hypothesis, based upon a more dynamic view of transcriptional states, reconciling the experimental evidence underpinning the traditional hypotheses. |
| Databáze: | OpenAIRE |
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