Morinda citrifolia L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in an In Vivo Experimental Model of Menopause

Autor: Supaporn Muchimapura, Cholathip Thipkaew, Terdthai Tong-Un, Wipawee Thukham-mee, Panakaporn Wannanon, Jintanaporn Wattanathorn
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2018 (2018)
ISSN: 1942-0900
DOI: 10.1155/2018/1039364
Popis: We aimed to determine the protective effects against cerebral ischemia and osteoporosis ofMorinda citrifoliaextract in experimental menopause. The neuroprotective effect was assessed by givingM. citrifolialeaf extract at doses of 2, 10, and 50 mg/kg BW to the bilateral ovariectomized (OVX) rats for 7 days. Then, they were occluded in the right middle cerebral artery (MCAO) for 90 minutes. The neurological score, brain infarction volume, oxidative stress status, and ERK1/2 and eNOS activities were assessed 24 hours later.M. citrifoliaimproved neurological score, brain infarction, and brain oxidative stress status in the cortex of OVX rats plus the MCAO. No changes in ERK 1/2 signal pathway and NOS expression were observed in this area. Our data suggested that the neuroprotective effect of the extract might occur partly via the improvement of oxidative stress status in the cortex. The antiosteoporotic effect in OVX rats was also assessed after an 84-day intervention ofM. citrifolia. The serum levels of calcium, osteocalcin, and alkaline phosphatase and osteoblast density in the tibia were increased, but the density of osteoclast was decreased in OVX rats which received the extract. Therefore, the current data suggested that the extract possessed antiosteoporotic effect by increasing bone formation but decreasing bone resorption.
Databáze: OpenAIRE
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