Modified Antiproteinase Hemosorbent
| Autor: | Valuev Lev I, I. V. Obydennova, L. V. Vanchugova, I. L. Valuev |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
0106 biological sciences
0301 basic medicine Polyacrylamide Hydrogel Polymers and Plastics Chemistry Hirudin High capacity 01 natural sciences Applied Microbiology and Biotechnology Biochemistry Serine proteinases 03 medical and health sciences 030104 developmental biology 010608 biotechnology medicine Materials Chemistry Ceramics and Composites medicine.drug |
| Zdroj: | Polymer Science, Series B. 64:354-357 |
| ISSN: | 1555-6123 1560-0904 |
| DOI: | 10.1134/s1560090422020075 |
| Popis: | A method to increase the thromboresistance of the biospecific antiproteinase hemosorbent was suggested based on simultaneous immobilization of duck egg ovomucoid and blood anticoagulant—heparin or hirudin—in the bulk of polyacrylamide hydrogel. It was demonstrated that modification of the hemosorbent with hirudin resulted in a significant increase of its compatibility with blood with simultaneous preservation of high capacity with regards to serine proteinases. |
| Databáze: | OpenAIRE |
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