Dopamine transporter binding in females with panic disorder may vary with clinical status
| Autor: | Jyrki T. Kuikka, David J. Nutt, Eduard Maron, Jari Tiihonen |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
medicine.medical_specialty Striatum Iodine Radioisotopes Young Adult chemistry.chemical_compound Dopamine Internal medicine mental disorders medicine Humans Neurotransmitter Biological Psychiatry Pain Measurement Dopamine transporter Psychiatric Status Rating Scales Tomography Emission-Computed Single-Photon Analysis of Variance Brain Mapping Dopamine Plasma Membrane Transport Proteins biology business.industry Panic disorder Binding potential Panic Organotechnetium Compounds Middle Aged medicine.disease Psychiatry and Mental health Endocrinology nervous system chemistry biology.protein Panic Disorder Female medicine.symptom business Anxiety disorder Protein Binding medicine.drug |
| Zdroj: | Journal of Psychiatric Research. 44:56-59 |
| ISSN: | 0022-3956 |
| Popis: | Background To date the involvement of dopamine system in neurobiology of panic disorder (PD) has been not investigated by imaging studies in humans. In this study, we evaluated the binding potential of dopamine transporter (DAT) in striatum of patients with PD. Methods Subjects comprised seven female patients with current PD, seven female PD patients in remission and seven female healthy controls, matched by age. Striatal DAT binding was evaluated using single-photon emission computed tomography and [ 123 I]nor-β-CIT tracer. Results Significantly higher DAT binding in striatum was detected in remitted PD females as compared with both currently ill PD and control females. The females with current PD demonstrated non-significant lowering in striatal DAT binding as compared with healthy controls. The correlation analysis in total sample of female patients showed significant and inverse relationship between striatal DAT binding characteristics and severity of panic symptoms. Conclusions This is first report showing that DAT binding in striatum may depend on the clinical status in females with PD. Our data suggest that increased level of DAT may contribute to stability of remission; however, the exact involvement of dopamine system in PD pathogenesis requires further investigations. The preliminary results of current study should be confirmed by other independent studies and should also be extended to include male patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect