Changes to the electrocardiogram during exercise in anorexia nervosa
| Autor: | Andrew D. Krahn, Josie Geller, Julia Raudzus, Nathaniel M. Hawkins, Christopher C. Cheung, Mikyla Janzen, Pei-Yoong Lam |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Anorexia Nervosa 030204 cardiovascular system & hematology Sudden death QT interval 03 medical and health sciences Electrocardiography Young Adult 0302 clinical medicine Heart Rate Internal medicine Heart rate medicine Repolarization Humans 030212 general & internal medicine Prospective Studies Prospective cohort study Lead (electronics) business.industry medicine.disease 3. Good health Eating disorders Long QT Syndrome Anorexia nervosa (differential diagnoses) Cardiology Exercise Test Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of electrocardiology. 61 |
| ISSN: | 1532-8430 |
| Popis: | Background Anorexia Nervosa (AN) is an eating disorder characterized by low body weight, distorted body image, and an intense fear of gaining weight. Electrocardiogram (ECG) changes, particularly in the QT interval, have been implicated in AN-associated sudden death but not well defined. Objectives To characterize QT interval changes during exercise in anorexia nervosa. Methods The QT interval was evaluated in a prospective cohort undergoing structured exercise. Patients from the St. Paul's Hospital Provincial Adult Tertiary Eating Disorders Program underwent a 6-minute modified exercise test protocol. A single lead ECG patch recording device was used to record a Lead I equivalent, due to challenges applying standard ECG monitoring in subjects with low body mass. Heart rate (HR) and QT interval were assessed. Results Eighteen eating disorder patients (16 female) completed testing (age 31 ± 12 years, BMI 16.5 ± 3.8 kg/m2). Patients were compared to age- and sex-matched healthy controls. HR was similar between patients and controls (baseline: 65 (55–70)bpm vs. 69 (53–73)bpm, p = 0.83; maximum: 110 (94–139) bpm vs. 108 (93–141) bpm, p = 0.96; end recovery: 62 (54–68) bpm vs. 66 (55–75) bpm, p = 0.39). QTc intervals were similar between groups at baseline (381 ± 17 ms vs. 381 ± 46 ms, p = 0.93) and end recovery (397 ± 42 ms vs 398 ± 42 ms, p = 0.91). However, AN patients demonstrated QTc prolongation while controls showed QTc shortening at maximum HR (426 ± 70 ms vs. 345 ± 59 ms, p = 0.001). Conclusion Low level exercise HR increases are similar between AN patients and controls, but the QTc interval fails to shorten, which may explain the increased arrhythmic risk in AN. |
| Databáze: | OpenAIRE |
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