5-Imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors

Autor:	Isabelle Noëlle Constance Pilatte, Walter Wouters, Geert Mannens, Yannick Aimé Eddy Ligny, Marc Venet, Pieter Van Remoortere, David W. End, Philippe Muller, Ann Devine, Patrick Rene Angibaud, Gerda Smets, Jacky Van Dun, Xavier Bourdrez, Stacy Skrzat, Virginie Sophie Poncelet, Eddy Jean Edgard Freyne
Rok vydání:	2003
Předmět:	Tertiary amine Stereochemistry Farnesyltransferase Clinical Biochemistry Pharmaceutical Science Antineoplastic Agents In Vitro Techniques Quinolones Biochemistry Chemical synthesis Mice Structure-Activity Relationship chemistry.chemical_compound Drug Discovery Animals Farnesyltranstransferase Humans Moiety Structure–activity relationship Molecular Biology Farnesyl-diphosphate farnesyltransferase Alkyl and Aryl Transferases biology Bicyclic molecule Chemistry Organic Chemistry Azepines Xenograft Model Antitumor Assays Microsomes Liver Quinazolines biology.protein Lactam Molecular Medicine Indicators and Reagents
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:1543-1547
ISSN:	0960-894X
Popis:	The evaluation of structure-activity relationships associated with the modification of the R115777 quinolinone ring moiety displaying potent in vitro inhibiting activity is described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b54561efa14f8a494a0c6d5b6e93280 https://doi.org/10.1016/s0960-894x(03)00180-x Zobrazit plný text záznamu Full Text from ScienceDirect