Evolution of heterochromatic genes of Drosophila
| Autor: | Jiro C. Yasuhara, Christine H. DeCrease, Barbara T. Wakimoto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Euchromatin
Heterochromatin Molecular Sequence Data Genes Insect Evolution Molecular Sequence Homology Nucleic Acid Gene cluster Constitutive heterochromatin Animals Enhancer Promoter Regions Genetic In Situ Hybridization Fluorescence Phylogeny Genetics Multidisciplinary biology Base Sequence Models Genetic fungi Chromosome Mapping Biological Sciences biology.organism_classification Drosophila melanogaster Multigene Family DNA Transposable Elements RNA Heterochromatin protein 1 Drosophila Orthologous Gene |
| Popis: | Heterochromatin is generally associated with gene silencing, yet in Drosophila melanogaster , heterochromatin harbors hundreds of functional protein-encoding genes, some of which depend on heterochromatin for expression. Here we document a recent evolutionary transition of a gene cluster from euchromatin to heterochromatin, which occurred Drosophila . Promoter type is diverse within the gene cluster but largely conserved between heterochromatic and euchromatic genes, eliminating the hypothesis that adaptation to heterochromatin required major alterations in promoter structure. Transition to heterochromatin is consistently associated with gene expansion due to the accumulation of transposable elements and increased A-T content. We conclude that heterochromatin-dependent regulation requires specialized enhancers or higher-order interactions and propose a facilitating role for transposable elements. |
| Databáze: | OpenAIRE |
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