Preparation of a polymeric reservoir naltrexone delivery device: effect of PEG content of the PLA membrane on drug release
| Autor: | Fatemeh Atyabi, Mahsa Alaee, Shadi H. Moghadam, Rassoul Dinarvand, Pantea Sayar |
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| Rok vydání: | 2005 |
| Předmět: |
chemistry.chemical_classification
Drug Chromatography business.industry medicine.drug_class media_common.quotation_subject technology industry and agriculture General Medicine Polymer Biodegradation Pharmacology Naltrexone chemistry.chemical_compound Membrane chemistry Polylactic acid PEG ratio medicine Pharmacology (medical) business Opioid antagonist medicine.drug media_common |
| Zdroj: | Therapy. 2:407-413 |
| ISSN: | 1744-831X 1475-0708 |
| DOI: | 10.2217/14750708.2.3.407 |
| Popis: | Background: Naltrexone is an orally active opioid agonist that has the potential for use as a treatment option for opiate addiction. However, in order for the drug to be effective, sufficient blood levels must be maintained for 4 to 8 months, which typically requires self-administration by the patient, resulting in complications. Aim: The aim of this study was to develop a polymeric reservoir device containing naltrexone. Materials & methods: The reservoir device was prepared using high-molecular-weight poly-l-lactide and the cylindrical device by dipping a stainless-steel rod in a methylene chloride solution of polylactic acid (PLA). High-molecular-weight PLA was used to take advantage of the low biodegradation rate of the polymer, in order to obtain constant drug release from the device based on the diffusion mechanism rather than biodegradation of the polymer. The impact of the polymeric device weight and polyethyleneglycol content of the polymeric membrane of the device on the release of naltrexone fr... |
| Databáze: | OpenAIRE |
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