Compensatory responses of left atrial conduit flow to atrial fibrillation with acute myocardial infarction in a canine model
| Autor: | Kazuya Murata, Takafumi Hiro, Hideld Kunichika, Hisanori Sakai, Masunori Matsuzaki |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Cardiac Volume Myocardial Infarction Diastole Doppler echocardiography Ventricular Function Left Dogs Left atrial Internal medicine Atrial Fibrillation medicine Animals Radiology Nuclear Medicine and imaging cardiovascular diseases Myocardial infarction Cardiac Output medicine.diagnostic_test business.industry P wave Hemodynamics Atrial fibrillation medicine.disease Echocardiography Doppler Disease Models Animal Pulmonary Veins Anesthesia cardiovascular system Cardiology Conduit flow Mitral Valve Atrial Function Left Cardiology and Cardiovascular Medicine business Beat (music) |
| Zdroj: | Journal of the American Society of Echocardiography. 14:1020-1024 |
| ISSN: | 0894-7317 |
| DOI: | 10.1067/mje.2001.113650 |
| Popis: | The aim of this study was to examine the interaction of acute atrial fibrillation (Af) and acute myocardial infarction (AMI) on left atrial (LA) and left ventricular (LV) filling in atrioventricular (A-V) sequential paced, open chest, anesthetized dogs. Left atrial conduit function was determined from pulmonary venous flow (PVF) and detailed analysis of early diastolic flow with the use of micromanometers and transmitral Doppler echocardiography. We studied 8 dogs with regular ventricular rates to avoid the confounding effect of ventricular arrhythmia in Af. In the control stage, Af increased the diastolic PVF volume to the left atrium compared with that during regular A-V pacing (from 0.58 +/- 0.11 mL/beat to 0.70 +/- 0.13 mL/beat, P.05), as a compensatory response to the impaired systolic PVF volume (from 0.56 +/- 0.12 mL/beat to 0.41 +/- 0.11 mL/beat, P.05). As a result, cardiac output was maintained. However, in the AMI stage, Af decreased cardiac output (from 0.95 +/- 0.32 L/min to 0.80 +/- 0.23 L/min, P.05 versus AMI with A-V pacing), and decreased diastolic PVF volume (from 0.46 +/- 0.13 mL/beat to 0.33 +/- 0.14 mL/beat, P.05 versus AMI with A-V pacing). These changes were associated with a prolonged LV isovolumic pressure decay rate. Our study demonstrates that Af does not affect cardiac output in the setting of normal LV function at a controlled ventricular rate because enhanced LA conduit flow compensates for impaired LA reservoir function. In contrast, in the setting of AMI, the compensatory response to Af is attenuated because of abnormal LV relaxation, resulting in a decrease in cardiac output. |
| Databáze: | OpenAIRE |
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