Synthesis of 9,9′-[1,2-Ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, an Impurity of Acyclovir
| Autor: | Antonio Cosme, Juan J. Vaquero, Rosa M. Suárez, Andrés Molina, Julio Alvarez-Builla, M. P. Matia, José Luis Novella |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Ethylene Glycol
Alkylation Stereochemistry Guanine Polymers Pharmaceutical Science Ring (chemistry) Medicinal chemistry Catalysis Article Analytical Chemistry chemistry.chemical_compound Impurity Formaldehyde Drug Discovery Physical and Theoretical Chemistry 2-Aminopurine Chemistry Organic Chemistry Benzenesulfonates Quaternary Ammonium Compounds Chemistry (miscellaneous) phase transfer catalysis Molecular Medicine Hydrochloric Acid acyclovir drug impurities Drug Contamination Acetamide nucleosides |
| Zdroj: | Molecules Volume 17 Issue 8 Pages 8735-8741 |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules17088735 |
| Popis: | The synthesis of 9,9'-[1,2-ethanediylbis(oxymethylene)]bis-2-amino-1,9-dihydro-6H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9-acetyl-6-oxo-1H-purin-2-yl)acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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