Analysis of latency time and its determinants in asbestos related malignant mesothelioma cases of the Italian register
| Autor: | Rosario Tumino, Marina Musti, Valerio Gennaro, Giuseppe Gorini, Enzo Merler, Pierpaolo Ferrante, F. Pannelli, Dario Mirabelli, Domenica Cavone, Fabio Montanaro, Antonio Romanelli, Renata De Zotti, Gabriella Cauzillo, M Menegozzo, Carolina Mensi, Alessandro Marinaccio, Alberto Scarselli, Alessandra Binazzi |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Mesothelioma Cancer Research Pathology medicine.medical_specialty Time Factors Pleural Neoplasms medicine.disease_cause Asbestos Heart Neoplasms Testicular Neoplasms Median latency medicine Humans Latency (engineering) Peritoneal Neoplasms Aged Univariate analysis business.industry Environmental Exposure Middle Aged medicine.disease Confidence interval Italy Oncology Latency stage Female Epidemiologic Methods business Pericardium Demography Linear trend |
| Zdroj: | European Journal of Cancer. 43:2722-2728 |
| ISSN: | 0959-8049 |
| DOI: | 10.1016/j.ejca.2007.09.018 |
| Popis: | Italy was an important producer of raw asbestos until 1992 (when it was banned) and it is now experiencing severe public health consequences due to large-scale industrial use of asbestos in shipbuilding and repair, asbestos-cement production, railways, buildings, chemicals and many other industrial sectors. Latency of malignant mesothelioma generally shows a large variability and the relationship with the modality of asbestos exposure is still not fully clarified. We present an analysis of latency period among the case list collected by the Italian mesothelioma register (ReNaM) in the period of diagnosis 1993-2001 (2544 malignant mesothelioma (MM) cases with asbestos exposure history). Exposure is assessed retrospectively by interview. Statistical univariate analyses were performed to estimate median and variability measures of latency time by anatomical site, gender and diagnosis period. The role of diagnostic confidence level, the morphology of the tumour and the modalities of asbestos exposure were verified in a regression multivariate model. We found a median latency period of 44.6 years increasing in recent years with a linear trend. Anatomical site, gender and morphology were not relevant for MM latency time whereas a shorter latency period was documented among occupationally exposed subjects (43 years) with respect to environmentally and household exposed ones (48 years). |
| Databáze: | OpenAIRE |
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