Absence of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected hemophiliacs
| Autor: | J. J. Sninsky, J. B. Jackson, J. R. Edson, Kim J. Sannerud, S. Y. Kwok, Henry H. Balfour, J. S. Hopsicker |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Immunology HIV Antibodies Hemophilia A Virus Serology law.invention Acquired immunodeficiency syndrome (AIDS) Antigen law HIV Seropositivity medicine Immunology and Allergy Humans Polymerase chain reaction Acquired Immunodeficiency Syndrome medicine.diagnostic_test biology business.industry virus diseases Hematology Middle Aged medicine.disease Virology Sexual Partners Immunoassay biology.protein HIV-1 Female Viral disease Antibody business |
| Zdroj: | Transfusion. 29(3) |
| ISSN: | 0041-1132 |
| Popis: | In order to confirm the presence and determine the frequency of human immunodeficiency virus, type 1 (HIV-1) infection prior to antibody production, 23 healthy women with histories of repeated unprotected sexual exposure to HIV-1 infected hemophiliacs were tested for evidence of HIV-1 infection. Female subjects were tested for HIV-1 antibody (enzyme immunoassay [EIA] and Western blot), HIV-1 serum antigen, HIV-1 DNA gag sequences by the polymerase chain reaction, and HIV-1 virus isolation from peripheral mononuclear cells. Twenty-two of 23 (96%) women were negative by all HIV-1 assays. One woman was positive by all the HIV-1 assays including an EIA screening test for HIV-1 antibody. These preliminary results suggest that the frequency of HIV-1 infection in antibody-negative sexual partners of HIV-1 infected individuals is probably very low. |
| Databáze: | OpenAIRE |
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