Immunogenicity of Haemophilus influenzae Type b Conjugate Vaccine in Allogeneic Bone Marrow Recipients
| Autor: | Luc Hessel, Bernard Fritzell, Jean-Louis Preud'homme, Liliane Intrator, Anne Barra, Marie-Pierre Preziosi, Catherine Cordonnier |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Haemophilus Infections health care facilities manpower and services Microgram complex mixtures Antigen Conjugate vaccine Haemophilus Tetanus Toxoid medicine Humans Transplantation Homologous Immunology and Allergy Bone Marrow Transplantation Vaccines Synthetic biology Tetanus business.industry Immunogenicity Polysaccharides Bacterial bacterial infections and mycoses biology.organism_classification medicine.disease Haemophilus influenzae Virology carbohydrates (lipids) Infectious Diseases medicine.anatomical_structure Immunoglobulin G Bacterial Vaccines Immunology biology.protein bacteria Female Bone marrow Antibody business Follow-Up Studies |
| Zdroj: | Journal of Infectious Diseases. 166:1021-1028 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1093/infdis/166.5.1021 |
| Popis: | A randomized study was conducted in 40 allogeneic marrow recipients to compare the immunogenicity of two Haemophilus influenzae type b (Hib) vaccines (either the Hib capsular polysaccharide [Hib-CPS] or tetanus toxoid-conjugated Hib-CPS [Hib-CPS-T]). A second injection consisted of Hib-CPS-T. Before immunization, 3 patients had serum antibody levels > 1 microgram/mL. After the first injection, the response was better after Hib-CPS-T than after Hib-CPS but lower than in normal subjects; a number of patients lacked any IgG antibody response, especially after Hib-CPS. Of patients who received two injections of Hib-CPS-T, 85% achieved an antibody concentration > or = 1 microgram/mL. Hib-CPS-T induced a response in IgG2-deficient patients whereas Hib-CPS alone did not. IgG antibodies predominantly belonged to the IgG1 subclass. The antibody response was better in patients immunized late after graft. This study shows that Hib-CPS-T is more immunogenic than Hib-CPS in marrow recipients. |
| Databáze: | OpenAIRE |
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