Tuning the conformation and mechanical properties of silk fibroin hydrogels
| Autor: | Narges Johari, Lorenzo Moroni, Ali Samadikuchaksaraei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
GROWTH-FACTOR
Materials science food.ingredient Polymers and Plastics CROSS-LINKING PHOTOCHEMICAL BEHAVIOR General Physics and Astronomy Fibroin Silk fibroin Mechanical properties 02 engineering and technology 010402 general chemistry DOUBLE-NETWORK HYDROGELS 01 natural sciences Gelatin SCAFFOLDS MESENCHYMAL STEM-CELLS NATURAL SILK food Mechanical properties of biomaterials Materials Chemistry EXTRACELLULAR-MATRIX GELATIN Organic Chemistry Treatment method Biomaterial HORSERADISH-PEROXIDASE 021001 nanoscience & nanotechnology 0104 chemical sciences Processing methods Treatment Chemical engineering Self-healing hydrogels 0210 nano-technology beta-sheet formation |
| Zdroj: | European Polymer Journal. 134 |
| ISSN: | 0014-3057 |
| DOI: | 10.1016/j.eurpolymj.2020.109842 |
| Popis: | Mechanical properties of biomaterials play an important role in their biological performance. Among the most important parameters in designing of biomaterials, their structure and conformation strongly affect their mechanical properties as well as cell adhesion, proliferation, and differentiation. Silk fibroin (SF), extracted from Bombyx mori cocoons, has attracted a lot of scientific interest in the past years as a natural biomaterial due to its exceptional host tissues response, appropriate mechanical properties, tunable degradation, simple processing method and low cost. The formation of β-sheets in the structure of SF enhances its mechanical properties. In recent years, several studies have focused on tuning the mechanical properties of SF for biomedical applications by inducing the formation of β-sheets. Some treatment methods have been introduced to alter SF structure and improve its mechanical properties. Chemical, physical and enzymatic crosslinking, water and alcoholic treatments and irradiations have been recommended as methods to inducing β-sheets conformation in SF structure. Several studies have developed these methods by adding suitable components and changing the concentration, temperature, humidity, pH, and various other parameters. In this review, we focus on the treatment methods, which result in the conformational transition of SF and tuning its mechanical properties. |
| Databáze: | OpenAIRE |
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