Selective oxidation of glycerol to mesoxalic acid by laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system: Effect of process conditions and the kinetic modeling
| Autor: | Gek Kee Chua, Sim Yee Chin, Chi Shein Hong, Chin Kui Cheng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Laccase
2 2 6 6-Tetramethylpiperidine Kinetic model General Chemical Engineering Mesoxalic acid food and beverages 02 engineering and technology General Chemistry 021001 nanoscience & nanotechnology Kinetic energy Process conditions chemistry.chemical_compound 020401 chemical engineering chemistry Glycerol Organic chemistry 0204 chemical engineering 0210 nano-technology |
| DOI: | 10.6084/m9.figshare.7660373.v1 |
| Popis: | A pharmaceutical importance compound, mesoxalic acid, can be produced through selective oxidation of glycerol using laccase/2,2,6,6-tetramethylpiperidine-N-oxyl system. Since mesoxalic acid is the fourth product in the serial oxidation, identification of the reaction conditions and its’ kinetic to maximize the production is essential. Hence, the objective of this study is to examine the effects of process conditions on the distribution of the products and the kinetic. Mesoxalic acid attained was 0.0712 M (>200% of control) at 19 °C, pH 5.5, 1:3 of glycerol/TEMPO ratio and TEMPO/laccase ratio of 9:3. To conclude, a moderate temperature that preserves the activity of laccase would favor the formation of mesoxalic acid. The serial chemical reactions could be expressed by a power law rate obtained via MATLAB through fitting of the experimental kinetic data. Oxidising from tartronic acid to mesoxalic acid was found to require higher activation energy (25.06 kJ/mol) as compared to other steps. |
| Databáze: | OpenAIRE |
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