Residential exposure to natural background radiation at birth and risk of childhood acute leukemia in France, 1990–2009

Autor: Stéphanie Goujon, Dominique Laurier, Justine Berlivet, Jacqueline Clavel, Enora Clero, Laure Faure, Denis Hémon, Géraldine Ielsch
Přispěvatelé: Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), ATHENA, Irsn, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Rok vydání: 2021
Předmět:
[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology
Ultraviolet Rays
Health
Toxicology and Mutagenesis
Childhood cancer
[SDV.CAN]Life Sciences [q-bio]/Cancer
Rate ratio
030218 nuclear medicine & medical imaging
03 medical and health sciences
symbols.namesake
[SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics
0302 clinical medicine
[SDV.CAN] Life Sciences [q-bio]/Cancer
Radiation Monitoring
[SDV.EE.SANT] Life Sciences [q-bio]/Ecology
environment/Health
natural background radiation
childhood cancer
Background Radiation
Humans
Environmental Chemistry
Medicine
Poisson regression
Cities
Waste Management and Disposal
Exposure assessment
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology
environment/Health
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
Acute leukemia
Leukemia
business.industry
Incidence (epidemiology)
gamma radiation
Infant
Newborn
Ecological study
radon
[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology
General Medicine
Pollution
3. Good health
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
030220 oncology & carcinogenesis
symbols
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
France
National registry
business
Demography
Zdroj: Journal of Environmental Radioactivity
Journal of Environmental Radioactivity, Elsevier, 2021, 233, pp.106613. ⟨10.1016/j.jenvrad.2021.106613⟩
Journal of Environmental Radioactivity, 2021, 233, pp.106613. ⟨10.1016/j.jenvrad.2021.106613⟩
ISSN: 0265-931X
1879-1700
Popis: International audience; Background: The role of natural background radiation (NBR) in childhood acute leukaemias (AL) remains unclear. Several large record based studies have recently reported heterogeneous results. The different exposure period considered in these studies may explain this heterogeneity. Objectives: In a previous ecological study we did not observe any association between childhood AL incidence in France and NBR exposure at the time of diagnosis. With the same methodology, the present study focused on NBR exposure during the prenatal period. Methods: The study population included all children born in mainland France between 1990 and 2009 (French residents). Based on the French national registry of childhood cancer, we included 5,932 childhood AL cases born and diagnosed during the study period. NBR levels in municipalities of residence at birth were estimated by cokriging models, using NBR measurements and precise geological data. The incidence rate ratio (IRR) per unit variation of exposure was estimated with Poisson regression models, with adjustment for socio-demographic indicators and ultraviolet radiation levels. NBR exposures were considered at the time of birth, and cumulatively from birth to diagnosis. We also estimated a total NBR dose to red-bone marrow. We analyzed all AL together, and the main types of AL separately.Results: There was no association between NBR exposure at birth and childhood AL incidence, neither overall (gamma radiation: IRR = 0.98 (0.93,1.04) per 50 nSv/h; radon concentration: IRR = 0.96 (0,90,1.02) per 100 Bq/m3) nor for the main AL types. The conclusions were similar with the cumulative exposures, and the total red-bone marrow dose. Conclusions: The study was based on high quality incidence data, large numbers of AL cases, and validated models of NBR exposure assessment. In all, the results further support the hypothesis that NBR are not associated to childhood AL in France, whatever the timing for exposure assessment.
Databáze: OpenAIRE
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