Residential exposure to natural background radiation at birth and risk of childhood acute leukemia in France, 1990–2009
Autor: | Stéphanie Goujon, Dominique Laurier, Justine Berlivet, Jacqueline Clavel, Enora Clero, Laure Faure, Denis Hémon, Géraldine Ielsch |
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Přispěvatelé: | Equipe 7 : EPICEA - Epidémiologie des cancers de l'enfant et de l'adolescent (CRESS - U1153), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS)-Institut National de la Santé et de la Recherche Médicale (INSERM), ATHENA, Irsn, Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
Rok vydání: | 2021 |
Předmět: |
[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology
Ultraviolet Rays Health Toxicology and Mutagenesis Childhood cancer [SDV.CAN]Life Sciences [q-bio]/Cancer Rate ratio 030218 nuclear medicine & medical imaging 03 medical and health sciences symbols.namesake [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics 0302 clinical medicine [SDV.CAN] Life Sciences [q-bio]/Cancer Radiation Monitoring [SDV.EE.SANT] Life Sciences [q-bio]/Ecology environment/Health natural background radiation childhood cancer Background Radiation Humans Environmental Chemistry Medicine Poisson regression Cities Waste Management and Disposal Exposure assessment [SDV.EE.SANT]Life Sciences [q-bio]/Ecology environment/Health [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics Acute leukemia Leukemia business.industry Incidence (epidemiology) gamma radiation Infant Newborn Ecological study radon [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology General Medicine Pollution 3. Good health [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie 030220 oncology & carcinogenesis symbols [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie France National registry business Demography |
Zdroj: | Journal of Environmental Radioactivity Journal of Environmental Radioactivity, Elsevier, 2021, 233, pp.106613. ⟨10.1016/j.jenvrad.2021.106613⟩ Journal of Environmental Radioactivity, 2021, 233, pp.106613. ⟨10.1016/j.jenvrad.2021.106613⟩ |
ISSN: | 0265-931X 1879-1700 |
Popis: | International audience; Background: The role of natural background radiation (NBR) in childhood acute leukaemias (AL) remains unclear. Several large record based studies have recently reported heterogeneous results. The different exposure period considered in these studies may explain this heterogeneity. Objectives: In a previous ecological study we did not observe any association between childhood AL incidence in France and NBR exposure at the time of diagnosis. With the same methodology, the present study focused on NBR exposure during the prenatal period. Methods: The study population included all children born in mainland France between 1990 and 2009 (French residents). Based on the French national registry of childhood cancer, we included 5,932 childhood AL cases born and diagnosed during the study period. NBR levels in municipalities of residence at birth were estimated by cokriging models, using NBR measurements and precise geological data. The incidence rate ratio (IRR) per unit variation of exposure was estimated with Poisson regression models, with adjustment for socio-demographic indicators and ultraviolet radiation levels. NBR exposures were considered at the time of birth, and cumulatively from birth to diagnosis. We also estimated a total NBR dose to red-bone marrow. We analyzed all AL together, and the main types of AL separately.Results: There was no association between NBR exposure at birth and childhood AL incidence, neither overall (gamma radiation: IRR = 0.98 (0.93,1.04) per 50 nSv/h; radon concentration: IRR = 0.96 (0,90,1.02) per 100 Bq/m3) nor for the main AL types. The conclusions were similar with the cumulative exposures, and the total red-bone marrow dose. Conclusions: The study was based on high quality incidence data, large numbers of AL cases, and validated models of NBR exposure assessment. In all, the results further support the hypothesis that NBR are not associated to childhood AL in France, whatever the timing for exposure assessment. |
Databáze: | OpenAIRE |
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