Noninvasive Treatment-Efficacy Evaluation for HIFU Therapy Based on Magneto-Acousto-Electrical Tomography
| Autor: | Gepu Guo, Zhengfeng Yu, Yan Zhou, Juan Tu, Qingyu Ma, Dong Zhang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Temperature monitoring
Materials science Phantoms Imaging 0206 medical engineering Electric Conductivity Temperature Biomedical Engineering 02 engineering and technology Models Biological 020601 biomedical engineering Pennes equation Treatment efficacy Focused ultrasound Stroke treatment Electrocoagulation High-Intensity Focused Ultrasound Ablation Tomography Hifu ablation Magneto Biomedical engineering |
| Zdroj: | IEEE Transactions on Biomedical Engineering. 66:666-674 |
| ISSN: | 1558-2531 0018-9294 |
| DOI: | 10.1109/tbme.2018.2853594 |
| Popis: | Objective: As a novel noninvasive modality of oncotherapy or stroke treatment, high-intensity focused ultrasound (HIFU) has drawn more and more attention in the past decades. Whereas, real-time temperature monitoring and treatment-efficacy evaluation are still the key issues for HIFU therapy. Methods: Based on the temperature–conductivity relation of tissues with a sharp conductivity variation of irreversible thermocoagulation at 69 °C, a noninvasive method of treatment-efficacy evaluation for HIFU ablation using the magneto-acousto-electrical tomography (MAET) technology is theoretically studied. By applying the nonlinear Khokhlov–Zabolotskaya–Kuznetsov equation and Pennes equation, a cylindrical model is established to simulate the distributions of pressure, temperature, and conductivity with the consideration of harmonic components. Results: The MAET signals are simulated to analyze the characteristics of the peak amplitude and the axial interval of the two clusters generated by the conductivity boundary of HIFU ablation. Conclusion: The axial interval can be used as the indictor to evaluate the size of HIFU ablation with the minimum axial width of one wavelength. Significance: The favorable results demonstrate the feasibility of real-time treatment-efficacy evaluation for HIFU therapy using the MAET technology and suggest potential applications in clinical practice. |
| Databáze: | OpenAIRE |
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