An acidic polysaccharide with immunological activities from the root of Paeonia lactiflora
| Autor: | Masashi Tomoda, Noriko Shimizu, Ryoko Gonda, Keiko Hirabayashi, Keiko Matsumoto, Naoko Ohara |
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| Rok vydání: | 1994 |
| Předmět: |
Paeonia lactiflora
Magnetic Resonance Spectroscopy Pharmaceutical Science Peptide In Vitro Techniques Lithium Polysaccharide Methylation Plant Roots Gel permeation chromatography Mice Phagocytosis Polysaccharides Animals Polyacrylamide gel electrophoresis Pharmacology chemistry.chemical_classification Complement Inactivator Proteins Mice Inbred ICR Chromatography Plants Medicinal Molecular mass biology Plant Extracts General Medicine Nuclear magnetic resonance spectroscopy biology.organism_classification Electrophoresis chemistry Biochemistry Chromatography Gel Electrophoresis Polyacrylamide Gel |
| Zdroj: | Biologicalpharmaceutical bulletin. 17(9) |
| ISSN: | 0918-6158 |
| Popis: | An acidic polysaccharide, called peonan PA, was isolated from the root of Paeonia lactiflora PALLAS. It was homogeneous on electrophoresis and gel chromatography, and its molecular mass was estimated to be 6.0 x 10(4). Peonan PA is composed of L-arabinose: D-galactose: D-galacturonic acid in the molar ratio of 2:1:10, in addition to small amounts of O-acetyl groups and peptide moieties. About forty percent of the hexuronic acid residues in peonan PA exist as methyl esters. Reduction of carboxyl groups, methylation analysis, lithium degradation and nuclear magnetic resonance studies indicated that its main structural features involve both alpha-1,5-linked L-arabino-beta-3,6-branched D-galactan type and alpha-1,4-linked D-galacturonan type structural units. The polysaccharide exhibited remarkable reticuloendothelial system-potentiating activity in a carbon clearance test and considerable anti-complementary activity. |
| Databáze: | OpenAIRE |
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