Increased Likelihood of Bacterial Pathogens in the Coronal Sulcus and Urethra of Uncircumcised Men in a Diverse Group of HIV Infected and Uninfected Patients in India
| Autor: | Chuanhong Liao, Dionysis Antonopoulos, Vemu Lakshmi, Sreenivasan Vadivelu, SV Prasad, Bhavesh V Trikamji, Eugene Chang, Shivani R. Kandukuri, John A. Schneider |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Staphylococcus aureus Tuberculosis Population Logistic regression lcsh:Infectious and parasitic diseases 03 medical and health sciences Foreskin 0302 clinical medicine Circumcision Internal medicine medicine Sex organ lcsh:RC109-216 030212 general & internal medicine education 030304 developmental biology 0303 health sciences education.field_of_study business.industry Coronal sulcus HIV Odds ratio medicine.disease 3. Good health Infectious Diseases Urethra medicine.anatomical_structure Immunology Original Article business |
| Zdroj: | Journal of Global Infectious Diseases Journal of Global Infectious Diseases, Vol 4, Iss 1, Pp 6-9 (2012) |
| ISSN: | 0974-8245 |
| Popis: | Background: The biological mechanism of circumcision as potentiating HIV prevention is poorly understood. Foreskin microbiota has been postulated as having a potential role; however, little is known about the relationship between bacterial pathogens and circumcision in adults. Materials and Methods: We sampled the coronal sulcus of a diverse group of circumcised and uncircumcised men (n=315) from a government chest hospital and fertility clinic in Hyderabad, Andhra Pradesh, India. Genital examination was conducted on three groups of men: Group 1 - HIV infected; Group 2 - TB infected; Group 3 - control. Aerobic and anaerobic specimens were cultured according to standard clinical protocols, and results were analyzed following multivariate logistic regression models. Results: Three hundred fifteen study participants - 47.6% of Group 1, 36.5% of Group 2, and 15.9% of Group 3 - were enrolled in the study and included in all analyses. Overall 37.1% of the participants were circumcised without variation across groups (P=0.29). Smegma was observed in 18.7% of the participants with no cases observed in Group 3 (P |
| Databáze: | OpenAIRE |
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