Biochemical and physiological effects of chlordimeform
| Autor: | R W Beeman, F Matsumura |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Tryptamine
Biogenic Amines Monoamine Oxidase Inhibitors Reserpine Receptors Drug Health Toxicology and Mutagenesis Chlordimeform Amidines Cockroaches Pharmacology Lethal Dose 50 Mice chemistry.chemical_compound In vivo biology.animal medicine Animals Arthropods Brain Chemistry Mites Cockroach Behavior Animal biology Public Health Environmental and Occupational Health Chlorphenamidine biology.organism_classification Rats respiratory tract diseases Electrophysiology Indolamines chemistry Octopamine (neurotransmitter) American cockroach Research Article medicine.drug |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| DOI: | 10.1289/ehp.761471 |
| Popis: | Chlordimeform is a relatively new acaricide/insecticide, whose mode of action we have investigated. It appears to interfere with amine-mediated control of nervous and endocrine systems in a variety of ways. Specifically, chlordimeform causes a build-up of the amines 5-hydroxytryptamine and to a lesser extent norepinephrine in the rat brain in vivo, antagonizes the in vivo action of reserpine in the rat (reserpine depletes amine stores in the CNS), inhibits monoamine oxidase from rat liver in vitro, and causes hypotension in rabbits. In the American cockroach it directly stimulates the heart in situ, acts synergistically with tryptamine in vivo, inhibits amine-N-acetyltransferase from cockroach head in vitro, causes accumulation of indolamines in cockroaches in vivo, and blocks the stimulation of adenylate cyclase by octopamine in the cockroach CNS in situ. It also inhibits tryptamine metabolism in whole mites in vitro. Images FIGURE 3. FIGURE 4. A FIGURE 4. B FIGURE 4. C FIGURE 4. D |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|