The prognostic impact of quality of life assessed with the EORTC QLQ-C30 in inoperable non-small cell lung carcinoma treated with radiotherapy

Autor: Guul P.M. ten Velde, Neil K. Aaronson, Martin J. Muller, Miel Wouters, H. Langendijk, Jos M.A. de Jong
Přispěvatelé: Radiotherapie, Pulmonologie, RS: NUTRIM School of Nutrition and Translational Research in Metabolism, RS: GROW - School for Oncology and Reproduction, Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
Jazyk: angličtina
Rok vydání: 2000
Předmět:
Oncology
Male
Multivariate analysis
Lung Neoplasms
medicine.medical_treatment
non-small cell lung carcinoma
CARES-SF
Quality of life
Carcinoma
Non-Small-Cell Lung
Surveys and Questionnaires
Activities of Daily Living
ONCOLOGY-GROUP
Prospective Studies
Prospective cohort study
ADVANCED BREAST-CANCER
Child
INSTRUMENT
OF-LIFE
Radiotherapy Dosage
Hematology
CHEMOTHERAPY
Middle Aged
Prognosis
humanities
Survival Rate
Child
Preschool
Lymphatic Metastasis
SURVIVAL
Female
CLINICAL-TRIALS
Adult
medicine.medical_specialty
Adolescent
QUESTIONNAIRE
Internal medicine
Weight Loss
medicine
Carcinoma
Humans
Radiology
Nuclear Medicine and imaging
Survival rate
radiotherapy
Aged
Neoplasm Staging
Proportional Hazards Models
Analysis of Variance
Performance status
business.industry
Proportional hazards model
prognostic factors
Infant
PERFORMANCE
medicine.disease
Surgery
Radiation therapy
Multivariate Analysis
Quality of Life
business
Follow-Up Studies
Zdroj: Radiotherapy and Oncology, 55, 19-25. Elsevier Ireland Ltd
Radiotherapy and Oncology, 55(1), 19-25. ELSEVIER IRELAND LTD
ISSN: 0167-8140
Popis: Purpose: The purpose of this study was to assess the prognostic significance of pretreatment quality of life (QoL) scores and symptom scores in a group of patients treated with high dose radiotherapy.Material and methods: A total of 198 patients treated with external irradiation ( greater than or equal to 60 Gy) were included. In all these patients, baseline QoL was assessed using the EORTC QLQ-C30. The prognostic significance of a number of non-QoL and QoL parameters with regard to survival was estimated in both univariate and multivariate analyses.Results: In a multivariate model including the non-QoL parameters, performance status, weight loss and N-classification were independent prognostic factors for survival. After entering the QoL parameters in the model, global QoL was the strongest prognostic factor, while performance status lost its significance. Subsequently, a significant interaction term was found between N-classification and global QoL, indicating that global QoL was an independent prognostic factor but that the effect varied as a function of N-status. In N+ patients, the median survival in the group with low scores for global QoL was 4.5 months, which was significantly worse (P Conclusion: Global QoL is a strong prognostic factor for survival in patients with NSCLC who have pathological lymph nodes at presentation and who are treated with radical or curative radiotherapy. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
Databáze: OpenAIRE
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