Motor training modulates intracortical inhibitory dynamics in motor cortex during movement preparation
| Autor: | Joshua Dupont-Hadwen, Sven Bestmann, Charlotte J. Stagg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Plasticity Movement medicine.medical_treatment education Biophysics Inhibitory postsynaptic potential Article 050105 experimental psychology lcsh:RC321-571 GABA 03 medical and health sciences 0302 clinical medicine medicine Humans Learning 0501 psychology and cognitive sciences Motor training lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry gamma-Aminobutyric Acid Movement preparation Motor skill GABAA receptor business.industry General Neuroscience 05 social sciences Neural Inhibition Evoked Potentials Motor Transcranial magnetic stimulation medicine.anatomical_structure Motor Skills Motor cortex GABAergic Female Neurology (clinical) Primary motor cortex Motor learning business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain Stimulation, Vol 12, Iss 2, Pp 300-308 (2019) Brain Stimul |
| ISSN: | 1935-861X |
| Popis: | Background The primary motor cortex (M1) has a vital role to play in the learning of novel motor skills. However, the physiological changes underpinning this learning, particularly in terms of dynamic changes during movement preparation, are incompletely understood. In particular, a substantial decrease in resting gamma-amino butyric acid (GABA) activity, i.e. a release of resting inhibition, is seen within M1 as a subject prepares to move. Although there is evidence that a decrease in resting inhibition occurs within M1 during motor learning it is not known whether the pre-movement “release” of GABAergic inhibition is modulated during skill acquisition. Objective Here, we investigated changes in pre-movement GABAergic inhibitory “release” during training on a motor skill task. Methods We studied GABAA activity using paired-pulse TMS (Short-Interval Intracortical Inhibition (SICI)) during training on a ballistic thumb abduction task, both at rest and at two time-points during movement preparation. Results Improvement in task performance was related to a later, steeper, release of inhibition during the movement preparation phase. Specifically, subjects who showed greater improvement in the task in the early stages of training showed a reduced level of GABAergic release immediately prior to movement compared with those who improved less. Later in training, subjects who performed better showed a reduction in GABAergic release early in movement preparation. Conclusions These findings suggest that motor training is associated with maintained inhibition in motor cortex during movement preparation. |
| Databáze: | OpenAIRE |
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