Entomophthoramycosis by Conidiobolus coronatus. Report of a case successfully treated with the combination of itraconazole and fluconazole
| Autor: | Maria de Lourdes Viegas, Márcia dos Santos Lazéra, Paulo Cezar Fialho Monteiro, Bodo Wanke, Antonio Carlos Francesconi do Valle |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Antifungal Agents Time Factors lcsh:Arctic medicine. Tropical medicine Itraconazole lcsh:RC955-962 RC955-962 Conidiobolus coronatus Rhinoentomophthoramycosis Zygomycosis Arctic medicine. Tropical medicine Amphotericin B Nose Diseases medicine Humans Conidiobolus Fluconazole Mycosis biology business.industry Entomophthoramycosis Nose Deformities Acquired General Medicine Middle Aged medicine.disease biology.organism_classification Dermatology Trimethoprim Infectious Diseases Treatment Outcome Combination triazole treatment Female business medicine.drug |
| Zdroj: | Revista do Instituto de Medicina Tropical de São Paulo; Vol. 43 No. 4 (2001); 233-236 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 43 Núm. 4 (2001); 233-236 Revista do Instituto de Medicina Tropical de São Paulo; v. 43 n. 4 (2001); 233-236 Revista do Instituto de Medicina Tropical de São Paulo Instituto de Medicina Tropical (IMT) instacron:IMT Revista do Instituto de Medicina Tropical de São Paulo, Vol 43, Iss 4, Pp 233-236 (2001) |
| ISSN: | 1678-9946 0036-4665 |
| Popis: | É relatado um caso de rinoentomoftoramicose por Conidiobolus coronatus em mulher de 61 anos submetida a tratamento com todos os antifúngicos disponíveis no mercado brasileiro, durante 8 anos, sem sucesso, incluindo iodeto de potássio por 1 mês, sulfametoxazol associado ao trimetoprim por 2 meses, anfotericina B em dose total de 1130 mg, cetoconazol, 400 mg/dia por 6 meses, fluconazol, 200 mg/dia, por pelo menos 2 meses, e itraconazol, 400 mg/dia, por 2 meses, seguido de 200 mg/dia por mais 4 meses. A cura clínica e micológica completa foi obtida com a associação de itraconazol 400mg/dia com fluconazol 200 mg/dia, durante 24 meses. Após a cura a paciente foi submetida a cirurgia restauradora. Atualmente a paciente encontra-se há 59 meses sem medicação específica permanecendo clínica e micologicamente curada. Rhinoentomophthoramycosis caused by Conidiobolus coronatus in a 61-year old woman was unsuccessfully treated during 8 years with all the antifungals available in the Brazilian market, including potassium iodide for 1 month, sulfamethoxazole plus trimethoprim for 2 months, amphotericin B, total dose of 1130 mg, cetoconazole, 400 mg/day for 6 months, fluconazole, 200 mg/day, for at least 2 months and, itraconazole, 400 mg/day for 2 months, followed by 200 mg/day for 4 more months. Complete clinical and mycological cure was achieved using itraconazol 400 mg/day in association with fluconazol 200 mg/day during 24 months. After cure she was submitted to plastic surgery to repair her facial deformation. Today she remains clinically and mycologically cured after 59/60 months (5 years!) without any specific antifungal. We thus suggest the use of the combination of itraconazole and fluconazole as an additional option for the treatment of this mycosis. |
| Databáze: | OpenAIRE |
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