Coronary Heart Disease, Peripheral Arterial Disease, and Stroke in Familial Hypercholesterolaemia
| Autor: | Perez de Isla, L, Alonso, R, Mata, N, Saltijeral, A, Muniz, O, Rubio-Marin, P, Diaz-Diaz, J, Fuentes, F, de Andres, R, Zambon, D, Galiana, J, Piedecausa, M, Aguado, R, Mosquera, D, Vidal, J, Ruiz, E, Manjon, L, Mauri, M, Padro, T, Miramontes, J, Mata, P, SAFEHEART Investigators |
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| Přispěvatelé: | [Perez de Isla, Leopoldo] Hosp Clin San Carlos, Dept Cardiol, IDISSC, Madrid, Spain, [Perez de Isla, Leopoldo] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Alonso, Rodrigo] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Mata, Nelva] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Saltijeral, Adriana] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Mata, Pedro] Fdn Hipercolesterolemia Familiar, C Gen Alvarez de Castro 14, Madrid 28010, Spain, [Alonso, Rodrigo] Clin Las Condes, Santiago, Chile, [Mata, Nelva] Madrid Hlth Author, Dept Epidemiol, Madrid, Spain, [Saltijeral, Adriana] Hosp Tajo, Dept Cardiol, Madrid, Spain, [Muniz, Ovidio] Hosp Virgen del Rocio, Dept Internal Med, Seville, Spain, [Rubio-Marin, Patricia] Hosp SAS Jerez Frontera, Dept Internal Med, Cadiz, Spain, [Diaz-Diaz, Jose L.] Hosp Abente & Lago, Dept Internal Med, La Coruna, Spain, [Fuentes, Francisco] Hosp Univ Reina Sofia, Dept Internal Med, Cordoba, Spain, [de Andres, Raimundo] Fdn Jimenez Diaz, Dept Internal Med, Madrid, Spain, [Zambon, Daniel] Hosp Clin Barcelona, Serv Endocrinol, Lipid Clin, Barcelona, Spain, [Galiana, Jesus] Hosp Univ Ciudad Real, Dept Internal Med, Ciudad Real, Spain, [Piedecausa, Mar] Hosp Univ Elche, Dept Internal Med, Alicante, Spain, [Alonso, Rodrigo] Hosp Gen Leon, Dept Endocrinol, Leon, Spain, [Mosquera, Daniel] Hosp San Pedro, Dept Internal Med, Logrono, Spain, [Vidal, Jose I.] Hosp Univ Lugo, Dept Endocrinol, Lugo, Spain, [Ruiz, Enrique] Hosp Univ Burgos, Dept Endocrinol, Burgos, Spain, [Manjon, Laura] Hosp Gijon, Dept Endocrinol, Asturias, Spain, [Mauri, Marta] Hosp Terrassa, Dept Internal Med, Barcelona, Spain, [Padro, Teresa] IIB St Pau, Inst Catalan Ciencias Cardiovasc, Barcelona, Spain, [Miramontes, Jose P.] Univ Hosp, Dept Internal Med, Salamanca, Spain, Fundacion Hipercolesterolemia Familiar, Instituto de Salud Carlos III |
| Rok vydání: | 2016 |
| Předmět: |
Male
Heredity Arterial disease Coronary Disease Comorbidity Disease Familial hypercholesterolemia 030204 cardiovascular system & hematology coronary disease 0302 clinical medicine Risk Factors Prevalence genetics Prospective Studies Registries 030212 general & internal medicine Age of Onset Stroke Molecular Epidemiology education.field_of_study hypercholesterolemia Smoking Middle Aged stroke Pedigree Peripheral Phenotype Apolipoprotein B-100 Female Cardiology and Cardiovascular Medicine Cohort study Adult Risk Heterozygote medicine.medical_specialty peripheral vascular diseases Population Risk Assessment Hyperlipoproteinemia Type II Peripheral Arterial Disease 03 medical and health sciences Sex Factors Internal medicine medicine Humans Genetic Predisposition to Disease education Aged States business.industry Statins medicine.disease Coronary heart disease Receptors LDL Spain Case-Control Studies Mutation Physical therapy business |
| Zdroj: | ARTERIOSCL THROM VAS r-FISABIO: Repositorio Institucional de Producción Científica Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO) r-FISABIO. Repositorio Institucional de Producción Científica instname ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/atvbaha.116.307514 |
| Popis: | Objective— Heterozygous familial hypercholesterolemia (FH) is the most common premature atherosclerotic cardiovascular disease (ASCVD)–related monogenic disorder, and it is associated with ischemic heart disease. There is limited information whether FH increases the risk of peripheral arterial and cerebrovascular disease. Our aim was to analyze ASCVD prevalence and characteristics in different arterial territories in a large FH population, to compare them with an unaffected control population and to determine which factors are associated to ASCVD. Approach and Results— SAFEHEART (Spanish Familial Hypercholesterolaemia Cohort Study) is an ongoing registry of molecularly defined patients with heterozygous FH in Spain. ASCVD in the different arterial territories was analyzed, as well as individual characteristics, genetic variables, and lipid-lowering therapies. The study recruited 4132 subjects (3745 ≥18 years); 2,752 of those enrolled were molecularly diagnosed FH cases. Median age was 44.0 years (45.9% men) and 40 years (46.6% men) in FH patients and unaffected relatives ( P P P 50 mg/dL were independently associated with ASCVD. Conclusions— The prevalence of ASCVD is higher, and the involvement of the arterial territories is different in FH patients when compared with their unaffected relatives. Age, male sex, increased body mass index, hypertension, type 2 diabetes mellitus, smoking habit, and lipoprotein(a) >50 mg/dL were independently associated to ASCVD. Clinical Trial Registration— URL: https://www.clinicaltrials.gov . Unique identifier: NCT02693548. |
| Databáze: | OpenAIRE |
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