Arrhythmogenic Right Ventricular Cardiomyopathy and Fatty Replacement of the Right Ventricular Myocardium
| Autor: | Allen P. Burke, Gerti Tashko, Renu Virmani, Andrew Farb |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease Heart Ventricles Cardiomyopathy Autopsy Sudden death Right ventricular cardiomyopathy Diagnosis Differential Fibrosis Physiology (medical) Internal medicine medicine Humans Arrhythmogenic Right Ventricular Dysplasia business.industry Middle Aged medicine.disease Death Sudden Cardiac medicine.anatomical_structure Adipose Tissue Ventricle Ventricular fibrillation Cardiology Female Cardiomyopathies Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 97:1571-1580 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.97.16.1571 |
| Popis: | Background —The relationship between arrhythmogenic right ventricular cardiomyopathy (ARVC) and pure fat replacement of the right ventricle is unclear. Methods and Results —Myocardial thickness, epicardial fat thickness, percent fibrosis, and intramyocardial fat infiltration were measured in 16 sections each from 25 hearts with typical (fibrofatty) ARVC, 7 hearts with fat replacement of the right ventricle without fibrosis (FaRV), and 18 control hearts from patients who died of noncardiac causes. Patients with fibrofatty ARVC were younger than those with FaRV (31±14 versus 44±13 years, P =.02), more likely to have a history of arrhythmias or a family history of premature sudden death (56% versus 0%, P =.01), more likely male (80% versus 29%, P =.02), and less likely to have coexisting conditions that might have predisposed to sudden death (12% versus 86%, P Conclusions —ARVC is a familial arrhythmogenic disease characterized by fibrofatty replacement of myocytes with scattered foci of inflammation. Fat infiltration per se is probably a different process that should not be considered synonymous with ARVC. |
| Databáze: | OpenAIRE |
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