5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
| Autor: | S. Henry, Robert Kiss, Antonio Evidente, Ramesh Dasari, Snezna Rogelj, Ria Kidner, Florence Lefranc, Véronique Mathieu, Liliya V. Frolova, Mary R. Reisenauer, Xiaojie Yu, Andrew Brenner, Alexander Pertsemlidis, Alexander V. Aksenov, Xiuye Ma, Igor V. Magedov, Alexander Kornienko, Jerry Pelletier, David Cavazos, Regina Cencic |
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| Přispěvatelé: | Henry, Sean, Kidner, Ria, Reisenauer, Mary R, Magedov, Igor V, Kiss, Robert, Mathieu, Véronique, Lefranc, Florence, Dasari, Ramesh, Evidente, Antonio, Yu, Xiaojie, Ma, Xiuye, Pertsemlidis, Alexander, Cencic, Regina, Pelletier, Jerry, Cavazos, David A, Brenner, Andrew J, Aksenov, Alexander V, Rogelj, Snezna, Kornienko, Alexander, Frolova, Liliya V. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Haemanthamine Amaryllidaceae Alkaloid medicine.medical_treatment Antineoplastic Agents Drug resistance Pharmacology Pharmacologie Multidrug resistance Lycorine Article Plant Extract Antineoplastic Agent 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Drug Discovery medicine Tumor Cells Cultured Humans Amaryllidaceae Alkaloids Chemotherapy Translation inhibition Bicyclic molecule Chemistry Plant Extracts Melanoma Organic Chemistry Amaryllidaceae General Medicine medicine.disease 3. Good health Multiple drug resistance Chimie organique 030104 developmental biology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer cell Apoptosis resistance Glioblastoma Human |
| Zdroj: | European journal of medicinal chemistry, 120 |
| Popis: | Plants of the Amaryllidaceae family produce a large variety of alkaloids and non-basic secondary metabolites, many of which are investigated for their promising anticancer activities. Of these, crinine-type alkaloids based on the 5,10b-ethanophenanthridine ring system were recently shown to be effective at inhibiting proliferation of cancer cells resistant to various pro-apoptotic stimuli and representing tumors with dismal prognoses refractory to current chemotherapy, such as glioma, melanoma, non-small-cell lung, esophageal, head and neck cancers, among others. Using this discovery as a starting point and taking advantage of a concise biomimetic route to the crinine skeleton, a collection of crinine analogues were synthetically prepared and evaluated against cancer cells. The compounds exhibited single-digit micromolar activities and retained this activity in a variety of drug-resistant cancer cell cultures. This investigation resulted in the discovery of new bicyclic ring systems with significant potential in the development of effective clinical cancer drugs capable of overcoming cancer chemotherapy resistance. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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